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Cotinine has an in vivo half-life of approximately 20 hours, and is typically detectable for several days (up to one week) after the use of tobacco. The level of cotinine in the blood, saliva, and urine is proportionate to the amount of exposure to tobacco smoke, so it is a valuable indicator of tobacco smoke exposure, including secondary (passive) smoke. [14]
The LD 50 of nicotine is 50 mg/kg for rats and 3 mg/kg for mice. 0.5–1.0 mg/kg can be a lethal dosage for adult humans, and 0.1 mg/kg for children. [19] [20] However the widely used human LD 50 estimate of 0.5–1.0 mg/kg was questioned in a 2013 review, in light of several documented cases of humans surviving much higher doses; the 2013 review suggests that the lower limit causing fatal ...
Nicotine is a hygroscopic, colorless to yellow-brown, oily liquid, that is readily soluble in alcohol, ether or light petroleum. It is miscible with water in its neutral amine base form between 60 °C and 210 °C. It is a dibasic nitrogenous base, having K b1 =1×10 −6, K b2 =1×10 −11. [ 163 ]
Hair test: Hair tests are reliable for long-term detection, showing nicotine use for one to three months. In some cases, nicotine can be detected for up to 12 months. In some cases, nicotine can ...
Drug test. MeSH. D015813. A drug test (also often toxicology screen or tox screen) is a technical analysis of a biological specimen, for example urine, hair, blood, breath, sweat, or oral fluid/saliva —to determine the presence or absence of specified parent drugs or their metabolites. Major applications of drug testing include detection of ...
Nicotine withdrawal is a group of symptoms that occur in the first few weeks after stopping or decreasing use of nicotine. Symptoms include intense cravings for nicotine, anger or irritability, anxiety, depression, impatience, trouble sleeping, restlessness, hunger, weight gain, and difficulty concentrating. [ 1 ][ 2 ][ 3 ] Withdrawal symptoms ...
Nicotine dependence[notes 2] is a state of substance dependence on nicotine. [3] It is a chronic, relapsing disease characterized by a compulsive craving to use the drug despite social consequences, loss of control over drug intake, and the emergence of withdrawal symptoms. [7] Tolerance is another component of drug dependence. [8]
An outbreak of e-cigarette, or vaping, product use-associated lung injury (EVALI) started in 2019 [ 3 ] among users of illegal, unregulated cannabis vaping products, [ 2 ] almost exclusively in the United States. [ 4 ] The first cases of this particular outbreak were identified in Illinois and Wisconsin in April 2019; as of 18 February 2020, a ...
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