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C-reactive protein (CRP) is an annular (ring-shaped) pentameric protein found in blood plasma, whose circulating concentrations rise in response to inflammation. It is an acute-phase protein of hepatic origin that increases following interleukin-6 secretion by macrophages and T cells .
The trial focused on patients with normal low-density lipoprotein (LDL) cholesterol levels but increased levels of high-sensitivity C-reactive protein (hs-CRP). JUPITER was the first clinical trial to indicate that statin therapy may provide benefit to patients with low-to-normal LDL levels and no known cardiovascular disease.
All participants had at least six tender and six swollen joints, and increased levels of high sensitivity C-reactive protein (hsCRP). [14] hsCRP is a substance produced by the body to protect itself from illness. [14] Trials lasted up to 5 years. [14] Trial 1 enrolled participants who had never been treated with methotrexate. [14]
People living in the intervention areas had 13% lower levels of high-sensitivity C-reactive protein, a blood marker associated with heart disease, including stroke, coronary artery disease and ...
He is responsible for the clinical development of high sensitivity C-reactive protein , a marker of inflammation, that is used to evaluate the risk of heart attack and stroke, and coined the term “residual inflammatory risk” to describe patients who are at risk due to vascular inflammation rather than high cholesterol levels.
The women with the highest levels of CRP had a 70% increased associated risk of heart disease, while the participants with the highest levels of LDL cholesterol and lipoprotein(a) had a 36% and 33 ...
More recently, additional risk indicators have been identified, e. g. type 2 allostatic load, [11] high-sensitivity C-reactive protein, d-dimer level, [12] renal failure [13] and altered thyroid function.
Retrieved from "https://en.wikipedia.org/w/index.php?title=HsCRP&oldid=254627123"This page was last edited on 28 November 2008, at 16:56 (UTC). (UTC).