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C-reactive protein (CRP) is an annular (ring-shaped) pentameric protein found in blood plasma, whose circulating concentrations rise in response to inflammation. It is an acute-phase protein of hepatic origin that increases following interleukin-6 secretion by macrophages and T cells .
The trial focused on patients with normal low-density lipoprotein (LDL) cholesterol levels but increased levels of high-sensitivity C-reactive protein (hs-CRP). JUPITER was the first clinical trial to indicate that statin therapy may provide benefit to patients with low-to-normal LDL levels and no known cardiovascular disease.
More recently, additional risk indicators have been identified, e. g. type 2 allostatic load, [12] high-sensitivity C-reactive protein, d-dimer level, [13] renal failure, [14] consumption of salt as sodium chloride, [6] and altered thyroid function.
He is responsible for the clinical development of high sensitivity C-reactive protein , a marker of inflammation, that is used to evaluate the risk of heart attack and stroke, and coined the term “residual inflammatory risk” to describe patients who are at risk due to vascular inflammation rather than high cholesterol levels.
Retrieved from "https://en.wikipedia.org/w/index.php?title=HsCRP&oldid=254627123"This page was last edited on 28 November 2008, at 16:56 (UTC). (UTC).
[89] [90] Ankle-brachial index (ABI), high-sensitivity C-reactive protein (hsCRP), and coronary artery calcium, are also of unclear benefit in those without symptoms as of 2018. [91] The NIH recommends lipid testing in children beginning at the age of 2 if there is a family history of heart disease or lipid problems. [92]
The method uses urine and blood tests to check inflammatory markers, such as a high-sensitivity C-reactive protein test (CRP) measuring CRP, a protein in found in blood that indicates inflammation throughout the body. [9]
All participants had at least six tender and six swollen joints, and increased levels of high sensitivity C-reactive protein (hsCRP). [14] hsCRP is a substance produced by the body to protect itself from illness. [14] Trials lasted up to 5 years. [14] Trial 1 enrolled participants who had never been treated with methotrexate. [14]
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