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Breast cancer metastatic mouse models are experimental approaches in which mice are genetically manipulated to develop a mammary tumor leading to distant focal lesions of mammary epithelium created by metastasis. Mammary cancers in mice can be caused by genetic mutations that have been identified in human cancer. This means models can be ...
The laboratory mouse has been instrumental in investigating the genetics of human disease, including cancer, for over 110 years. [1] The laboratory mouse has physiology and genetic characteristics very similar to humans providing powerful models for investigation of the genetic characteristics of disease.
Many PDX models have been successfully established for breast, prostate, colorectal, lung, and many other cancers because there are distinctive advantages when using PDX over cell lines for drug safety and efficacy studies as well as predicting patient tumor response to certain anti-cancer agents. [11]
4T1 is a breast cancer cell line derived from the mammary gland tissue of a mouse BALB/c strain. [ 1 ] 4T1 cells are epithelial and are resistant to 6-thioguanine . [ 1 ] In preclinical research, 4T1 cells have been used to study breast cancer metastasis as they can metastasize to the lung, liver, lymph nodes, brain and bone.
Mouse models of breast cancer metastasis Metadata This file contains additional information, probably added from the digital camera or scanner used to create or digitize it.
This is a list of major breast cancer cell lines that are primarily used in breast cancer research. [Notes 1] List of cell lines. Cell line Primary tumor
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Using mouse models, he developed assays to determine which cell types were more prone to migration away from the primary tumor. His research identified the lead migratory cancer cell to be K14+ across several models for breast cancer. [ 3 ]