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Development of solid lipid nanoparticles is one of the emerging fields of lipid nanotechnology (for a review on lipid nanotechnology, see [17]) with several potential applications in drug delivery, clinical medicine and research, as well as in other disciplines. Due to their unique size-dependent properties, lipid nanoparticles can possibly ...
SLNs can be made by replacing the liquid lipid oil used in the emulsion process with a solid lipid. In solid lipid nanoparticles, the drug molecules are dissolved in the particle's solid hydrophobic lipid core, this is called the drug payload, and it is surrounded by an aqueous solution. [6]
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Traditionally, LNPs are composed of four indispensable lipid components: an ionizable amino lipid that aids in both escaping the endosomes and binding nucleic acids to the particle, an amphipathic phospholipid that promotes fusion with the target cell and endosomes, cholesterol to enhance nanoparticle stability, and a polyethylene glycol lipid ...
Solid lipid nanoparticles (SLNs) are made up of solid lipids forming a matrix and stabilized by surfactants. They exhibit high physical stability and remain in solid state at different temperatures. Based on a study, intranasal delivery of SLNs loaded with rivastigmine tartrate (RT) exhibited no toxicity, stability, and improved bioavailability ...
The SNALPs ranged from 71 – 84 nm in size and were composed of synthetic cholesterol, phospholipid DSPC, PEG lipid PEGC-DMA, and cationic lipid DLinDMA at the molar ratio of 48:20:2:30. [10] The results confirm complete protection against viremia and death in guinea pigs when administered a SNALP-siRNA delivery system after diagnosis of the ...
Advances in lipid nanotechnology were instrumental in engineering medical nanodevices and novel drug delivery systems, as well as in developing sensing applications. [32] Another system for microRNA delivery under preliminary research is nanoparticles formed by the self-assembly of two different microRNAs to possibly shrink tumors. [33]
Pieter Rutter Cullis FRS FRSC OBC OC is a Canadian physicist and biochemist known for his contributions to the field of lipid nanoparticles (LNP). [1] Cullis and co-workers have been responsible for fundamental advances in the development of nanomedicines employing lipid nanoparticle (LNP) technology for cancer therapies, gene therapies and vaccines.
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