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Intercellular transfer of mitochondria in culture has been documented from MSCs and endothelial cells to breast cancer cell lines, ovarian cancer cell lines or to osteosarcoma cell line. [11] Mitochondrial transfer can occur also between cancer cells such as mesothelioma [12] and laryngeal carcinoma cells. [13]
Osteocytes, the most common cell type within mature cortical bone, actively participate in the growth and maintenance of TCVs through the transfer of mitochondria to endothelial cells. Scanning electron microscopy images have revealed that osteocytes possess numerous dendritic processes with expanded, endfoot-like structures. These endfeet ...
Malignant cancer cells can connect via tunneling nanotubes. [33] Tunneling nanotubes have been implicated as one mechanism by which whole mitochondria can be transferred from cell to cell. [7] A recent study in Nature Nanotechnology has reported that cancer cells can hijack the mitochondria from immune cells via physical tunneling nanotubes. [34]
The mitochondria-associated ER membranes (MAMs), play role in cell death modulation. Mitochondrial outer membrane permeabilization (MOMP), is a reason of the higher matrix Ca 2+ levels, which is acts as a trigger for apoptosis. MOMP is the process before apoptosis, which is accompanied to permeability of the inner membrane of the mitochondria ...
A mitochondrion (pl. mitochondria) is an organelle found in the cells of most eukaryotes, such as animals, plants and fungi.Mitochondria have a double membrane structure and use aerobic respiration to generate adenosine triphosphate (ATP), which is used throughout the cell as a source of chemical energy. [2]
The uneven distribution of sterols among the membranes of the cell organelles, depends largely on non-vesicular route of transfer.For instance, in the ER, where they are synthetised, they account for about the 5%, but they are far more concentrated in the PM, where they account for more than 30% of lipid content.
The endothelium (pl.: endothelia) is a single layer of squamous endothelial cells that line the interior surface of blood vessels and lymphatic vessels. [1] The endothelium forms an interface between circulating blood or lymph in the lumen and the rest of the vessel wall.
Simplified structure of a mitochondrion. The intermembrane space (IMS) is the space occurring between or involving two or more membranes. [1] In cell biology, it is most commonly described as the region between the inner membrane and the outer membrane of a mitochondrion or a chloroplast.