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Canine cognitive dysfunction (CCD) is a disease prevalent in dogs that exhibit symptoms of dementia or Alzheimer's disease shown in humans. [1] CCD creates pathological changes in the brain that slow the mental functioning of dogs resulting in loss of memory, motor function, and learned behaviors from training early in life.
The AKC reports that one study found that 28% of dogs between 11 and 12 years of age have at least one sign of dog dementia, and that increased to 68% in dogs over 15 years of age.
GME is likely second only to encephalitis caused by canine distemper virus as the most common cause of inflammatory disease of the canine CNS. [1] The disease is more common in female dogs of young and middle age. It has a rapid onset. The lesions of GME exist mainly in the white matter of the cerebrum, brainstem, cerebellum, and spinal cord. [2]
Positron emission tomography (PET) [1] is a functional imaging technique that uses radioactive substances known as radiotracers to visualize and measure changes in metabolic processes, and in other physiological activities including blood flow, regional chemical composition, and absorption. Different tracers are used for various imaging ...
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Positron emission tomography–magnetic resonance imaging (PET–MRI) is a hybrid imaging technology that incorporates magnetic resonance imaging (MRI) soft tissue morphological imaging and positron emission tomography (PET) functional imaging. [1] The combination of PET and MRI was mentioned in a 1991 Phd thesis by R. Raylman. [2]
In analysis of the fetal brain, MRI provides more information about gyration than ultrasound. [24] MRI is sensitive for the detection of brain abscess. [25] A number of different imaging modalities or sequences can be used with imaging the nervous system: T 1-weighted (T1W) images: Cerebrospinal fluid is dark.
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