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Streptomycin is an aminoglycoside. [3] It works by blocking the ability of 30S ribosomal subunits to make proteins, which results in bacterial death. [3] Albert Schatz first isolated streptomycin in 1943 from Streptomyces griseus. [5] [6] It is on the World Health Organization's List of Essential Medicines. [7]
In addition, some Mycobacteria, including the bacteria that cause tuberculosis, are susceptible to aminoglycosides. Streptomycin was the first effective drug in the treatment of tuberculosis, though the role of aminoglycosides such as streptomycin and amikacin has been eclipsed (because of their toxicity and inconvenient route of administration ...
The systematic name of this enzyme class is ATP:streptomycin 3"-adenylyltransferase. Other names in common use include streptomycin adenylate synthetase , streptomycin adenyltransferase , streptomycin adenylylase , streptomycin adenylyltransferase , streptomycin-spectinomycin adenylyltransferase , AAD (3") , and aminoglycoside 3 ...
Aminoglycoside. The standard treatment is with a minimum of four weeks of high-dose intravenous penicillin with an aminoglycoside such as gentamicin. The use of high-dose antibiotics is largely based upon animal models. [2] Leo Loewe of Brooklyn Jewish Hospital was the first to successfully treat subacute bacterial endocarditis with penicillin ...
Aminoglycosides are a class of antibiotics. The most frequently used aminoglycosides include gentamicin, amikacin and streptomycin. These antibiotics are usually used in combination with other antimicrobial agents to treat drug-resistant organisms. For example, they are used with β-lactam for bacterial infections in pneumonia. [7]
Tetracyclines, rifampicin, and the aminoglycosides streptomycin and gentamicin: Yes [5] Yersinia pestis: Bubonic plague: Culture Aminoglycosides such as streptomycin and gentamicin, tetracyclines (especially doxycycline), and the fluoroquinolone ciprofloxacin: Under research [6] usually Burkholderia cepacia and other Burkholderia species ...
Backup treatments can have serious side-effects; for example, antibiotics like aminoglycosides (such as amikacin, gentamicin, kanamycin, streptomycin, etc.) used for the treatment of drug-resistant tuberculosis and cystic fibrosis can cause respiratory disorders, deafness and kidney failure. [241] [242]
This involves the administration of a broad-spectrum antibiotic based on the signs and symptoms presented and is initiated pending laboratory results that can take several days. [34] [35] When the responsible pathogenic microorganism is already known or has been identified, definitive therapy can be started. This will usually involve the use of ...