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Methylphenidate taken by mouth has a bioavailability of 11–52% with a duration of action around 2–4 hours for instant-release (i.e. Ritalin), 3–8 hours for sustained-release (i.e. Ritalin SR), and 8–12 hours for extended-release (i.e. Concerta).
A tablet (also known as a pill) is a pharmaceutical oral dosage form (oral solid dosage, or OSD) or solid unit dosage form. Tablets may be defined as the solid unit dosage form of medication with suitable excipients. It comprises a mixture of active substances and excipients, usually in powder form, that are pressed or compacted into a solid ...
In Thailand, it went by ya khayan ('hard-working pill'), then as ya maa ('horse medicine'), and then ya ba ('crazy pill') in 1996. [5] According to an episode of the television series Drugs, Inc. , it is commonly referred to in north Thailand as chocalee , due to its alleged sweet taste and chocolatey smell. [ 6 ]
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The oldest known tablet inscribed with the Ten Commandments from the Old Testament sold on Wednesday for $5.04 million, more than double its high estimate. The stone, which dates back around 1,500 ...
MDPV undergoes CYP450 2D6, 2C19, 1A2, [19] and COMT phase 1 metabolism (liver) into methylcatechol and pyrrolidine, which in turn are glucuronated (uridine 5'-diphospho-glucuronosyl-transferase) allowing it to be excreted by the kidneys, with only a small fraction of the metabolites being excreted into the stools. [20]