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The three main mechanisms by which osteoporosis develops are an inadequate peak bone mass (the skeleton develops insufficient mass and strength during growth), excessive bone resorption, and inadequate formation of new bone during remodeling, likely due to mesenchymal stem cells biasing away from the osteoblast and toward the marrow adipocyte ...
Osteoporosis occurs when there is an imbalance between the bone resorption activities of osteoclasts and the bone formation activities of osteoblasts. [23] Osteoclast activity is also mediated by the interaction of two molecules produced by osteoblasts, namely osteoprotegerin and RANK ligand. These molecules also regulate differentiation of the ...
The cell body varies in size from 5–20 micrometers in diameter and contain 40–60 cell processes per cell, [4] with a cell to cell distance between 20–30 micrometers. [3] A mature osteocyte contains a single nucleus that is located toward the vascular side and has one or two nucleoli and a membrane. [5]
Bone marrow adipocytes (BMAds) [9] originate from mesenchymal stem cell (MSC) progenitors that also give rise to osteoblasts, among other cell types. [10] Thus, it is thought that BMAT results from preferential MSC differentiation into the adipocyte, rather than osteoblast, lineage in the setting of osteoporosis. [11]
panophobia, panopticon, pancytopenia (deficiency in all blood cell types - erythrocytes, leukocytes, thrombocytes) [9] papill-of or pertaining to the nipple (of the chest/breast) Latin papilla, nipple; diminutive of papula (see below) papillitis: papul(o)-Indicates papulosity, a small elevation or swelling in the skin, a pimple, swelling
When it comes to blockbuster weight-loss drugs like Wegovy and Ozempic, opinion among some of President-elect Donald Trump’s top advisers and health policy nominees appears deeply split.
Various figures from around the MLB have criticized commissioner Rob Manfred’s suggestion of a Golden At-Bat rule, which would allow managers to send anyone they like to the plate once per game.
A giant cell (also known as a multinucleated giant cell, or multinucleate giant cell) is a mass formed by the union of several distinct cells (usually histiocytes), often forming a granuloma. [ 1 ] Although there is typically a focus on the pathological aspects of multinucleate giant cells (MGCs), they also play many important physiological roles.