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High-dose estrogen therapy, which results in marked or complete suppression of testicular testosterone production such that testosterone levels are within the castrate range (95% decrease, to less than 50 ng/dL), causes decreased sexual desire and function.
Drugs and sexual desire is about sexual desire being manipulated through drugs from various approaches. Sexual desire is generated under the effects from sex hormones and microcircuits from brain regions. [1] Neurotransmitters play essential roles in stimulating and inhibiting the processes that lead to libido production in both men and women.
Hyperandrogenism, especially high levels of testosterone, can cause serious adverse effects if left untreated. High testosterone levels are associated with other health conditions such as obesity, hypertension, amenorrhea (cessation of menstrual cycles), and ovulatory dysfunction, which can lead to infertility.
Libido is primarily regulated by the hypothalamus, where sex hormones (testosterone and estrogen), and neurotransmitters (dopamine, oxytocin and serotonin), are the main components that influence sex drive.
It is typically released at periods of high stress designed to help the individual cope with stressful situations. [1] Cortisol secretion results in increased heart rate and blood pressure and the temporary shut down of metabolic processes such as digestion, reproduction, growth, and immunity as a means of conserving energy for the stress response.
Adrenaline temporarily provides increased muscular tonus, increased blood pressure due to peripheral vasoconstriction and tachycardia, and increased glucose in blood. There is also some activation of the HPA axis, producing glucocorticoids (cortisol, aka the S-hormone or stress-hormone).
To illustrate, the long-term exposure to stress creates a high level of these hormones. This may lead to high blood pressure (and subsequently heart disease), damage to muscle tissue, inhibition of growth, [9] and damage to mental health. Chronic stress also relates directly to the functionality and structure of the nervous system, thereby ...
Sodium levels also see an increase which results in fluid retention in tissues and elevated blood pressure. In addition to hypersecretion of cortisol, excess androgens are secreted. [8] In females, increased secretion of androgens, such as testosterone, results in masculinization which may present as facial hair growth and a deepened voice. [2]