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Like many other medical conditions, obesity is the result of an interplay between environmental and genetic factors. [2] [3] Studies have identified variants in several genes that may contribute to weight gain and body fat distribution, although only in a few cases are genes the primary cause of obesity.
Fat mass and obesity-associated protein, also known as alpha-ketoglutarate-dependent dioxygenase FTO, is an enzyme that in humans is encoded by the FTO gene located on chromosome 16. As one homolog in the AlkB family proteins, it is the first messenger RNA (mRNA) demethylase that has been identified. [ 5 ]
67980 Ensembl ENSG00000163281 ENSMUSG00000029209 UniProt Q8TDQ7 Q9CRC9 RefSeq (mRNA) NM_001270880 NM_001270881 NM_138335 NM_001038015 NM_027681 NM_001347363 NM_001359239 RefSeq (protein) NP_001257809 NP_001257810 NP_612208 NP_001033104 NP_001334292 NP_001346168 Location (UCSC) Chr 4: 44.68 – 44.73 Mb Chr 5: 69.73 – 69.75 Mb PubMed search Wikidata View/Edit Human View/Edit Mouse Glucosamine ...
The following is a list of genetic disorders and if known, type of mutation and for the chromosome involved. Although the parlance "disease-causing gene" is common, it is the occurrence of an abnormality in the parents that causes the impairment to develop within the child.
Obesity is a disease characterized by having excessive body fat, increasing a person’s risk for many serious health problems, such as heart disease, diabetes, and even some cancers.
The obesity rate among U.S. adults fell in 2023 for the first time in over a decade, according to a new study released on Friday. The study published in the journal JAMA Health Forum found that ...
16p11.2 deletion syndrome is a rare genetic condition caused by microdeletion on the short arm of chromosome 16. Most affected individuals experience global developmental delay and intellectual disability, as well as childhood-onset obesity. [1] 16p11.2 deletion is estimated to account for approximately 1% of autism spectrum disorder cases. [3] [4]
Obesity dipped slightly in U.S. adults last year for the first time in more than a decade, a study found. The researchers suggested that might be due, in part, to the rise of weight loss drugs ...