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Dicloxacillin is a narrow-spectrum β-lactam antibiotic of the penicillin class. [1] It is used to treat infections caused by susceptible (non-resistant) Gram-positive bacteria . [ 1 ] It is active against beta-lactamase -producing organisms such as Staphylococcus aureus , which would otherwise be resistant to most penicillins .
Cloxacillin is used against staphylococci that produce beta-lactamase, due to its large R chain, which does not allow the beta-lactamases to bind. This drug has a weaker antibacterial activity than benzylpenicillin, and is devoid of serious toxicity except for allergic reactions. [citation needed]
Scalp folliculitis is a skin condition that occurs when the hair follicles on the scalp become inflamed. This results in pustules, whiteheads, or other pimple-like bumps on the scalp that can be ...
The two types of beta-lactamases work on the basis of the two basic mechanisms of opening the β-lactam ring. [2] The SBLs are similar in structure and mechanistically to the β-lactam target penicillin-binding proteins (PBPs) which are necessary for cell wall building and modifying. SBLs and PBPs both covalently change an active site serine ...
Flucloxacillin has similar pharmacokinetics, antibacterial activity, and indications to dicloxacillin, and the two agents are considered interchangeable. It is reported to have higher, though rare, incidence of severe hepatic adverse effects than dicloxacillin, [ 28 ] but a lower incidence of renal adverse effects.
It is also licensed for the treatment of anthrax, actinomycosis, cervicofacial disease, thoracic and abdominal disease, clostridial infections, botulism, gas gangrene (with accompanying debridement and/or surgery as indicated), tetanus (as an adjunctive therapy to human tetanus immune globulin), diphtheria (as an adjunctive therapy to antitoxin ...
What is N-nitroso-duloxetine? In layman's terms, N-nitroso-duloxetine simply refers to a specific impurity that can be found in duloxetine. It is a type of nitrosamine specific to duloxetine and ...
In humans, Staphylococcus aureus is part of the normal microbiota present in the upper respiratory tract, [2] and on skin and in the gut mucosa. [3] However, along with similar bacterial species that can colonize and act symbiotically, they can cause disease if they begin to take over the tissues they have colonized or invade other tissues; the ...