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Diabetes and deafness (DAD) or maternally inherited diabetes and deafness (MIDD) or mitochondrial diabetes is a subtype of diabetes which is caused from a mutation in mitochondrial DNA, which consists of a circular genome. It is associated with the genes MT-TL1, MT-TE, and MT-TK. [1]
Microangiopathy in diabetes results from glycoprotein accumulation and endothelial damage, affecting highly microvascular structures like the cochlea. Studies have linked factors such as HbA1c levels, uncontrolled blood sugar, diabetic neuropathy, retinopathy and nephropathy to an increased risk of hearing loss in diabetic patients.
This is an accepted version of this page This is the latest accepted revision, reviewed on 17 December 2024. Group of endocrine diseases characterized by high blood sugar levels This article is about the common insulin disorder. For the urine hyper-production disorder, see Diabetes insipidus. For other uses, see Diabetes (disambiguation). Medical condition Diabetes mellitus Universal blue ...
This condition was first discovered in 1995 by Melberg et al. when they described 5 members of a 4-generation Swedish family where cerebellar ataxia and sensorineural deafness presented as an autosomal dominant trait, 4 of them had narcolepsy and 2 had diabetes mellitus. The oldest members had psychiatric symptoms, neurological anomalies, and ...
Various hereditary conditions may feature diabetes, for example myotonic dystrophy and Friedreich's ataxia. Wolfram's syndrome is an autosomal recessive neurodegenerative disorder that first becomes evident in childhood. It consists of diabetes insipidus, diabetes mellitus, optic atrophy, and deafness, hence the acronym DIDMOAD. [20]
Maternally inherited diabetes and deafness; Mathieu–De Broca–Bony syndrome; Matsoukas–Liarikos–Giannika syndrome; Matthew–Wood syndrome; Maturity onset diabetes of the young; Maumenee syndrome; Maxillary double lip; Maxillofacial dysostosis; Maxillonasal dysplasia, Binder type; Mayer–Rokitanski–Kuster syndrome; May–Hegglin anomaly
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Type 2 diabetes (T2D), formerly known as adult-onset diabetes, is a form of diabetes mellitus that is characterized by high blood sugar, insulin resistance, and relative lack of insulin. [6] Common symptoms include increased thirst , frequent urination , fatigue and unexplained weight loss . [ 3 ]