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The ventral tegmental area (VTA) (tegmentum is Latin for covering), also known as the ventral tegmental area of Tsai, [1] or simply ventral tegmentum, is a group of neurons located close to the midline on the floor of the midbrain.
The tegmentum area includes various different structures, such as the rostral end of the reticular formation, several nuclei controlling eye movements, the periaqueductal gray matter, the red nucleus, the substantia nigra, and the ventral tegmental area. [3] The tegmentum is the location of several cranial nerve nuclei. The nuclei of CN III and ...
The tegmentum which forms the floor of the midbrain, is ventral to the cerebral aqueduct. Several nuclei, tracts, and the reticular formation are contained here. The ventral tegmental area (VTA) is composed of paired cerebral peduncles. These transmit axons of upper motor neurons.
Referred to as the reward pathway, mesolimbic pathway projects from the ventral tegmental area to the ventral striatum (VTA → Ventral striatum [nucleus accumbens and olfactory tubercle]). [17] When a reward is anticipated, the firing rate of dopamine neurons in the mesolimbic pathway increases. [21]
The mesocortical pathway is a dopaminergic pathway that connects the ventral tegmentum to the prefrontal cortex. It is one of the four major dopamine pathways in the brain . It is essential to the normal cognitive function of the dorsolateral prefrontal cortex (part of the frontal lobe), and is thought to be involved in cognitive control ...
This processed information is often relayed to a collection of structures from the telencephalon, diencephalon, and mesencephalon, including the prefrontal cortex, cingulate gyrus, limbic thalamus, hippocampus including the parahippocampal gyrus and subiculum, nucleus accumbens (limbic striatum), anterior hypothalamus, ventral tegmental area ...
We mentioned dopamine a few paragraphs ago, which is produced in the neurons of two brain regions known as the substantia nigra (because of its dark color under the microscope) and the ventral ...
The region includes the tegmentum, crus cerebri and pretectum. By this definition, the cerebral peduncles are also known as the basis pedunculi, while the large ventral bundle of efferent fibers is referred to as the cerebral crus (crus means ‘leg’ in Latin.) or the pes pedunculi (pes means 'foot' in Latin.).