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Other first-line treatment options for blood pressure and heart disease are now considered before Viagra. ... potentially causing heart failure. Viagra can help reduce blood pressure in the lungs ...
This could result in less blood and oxygen getting to your heart, which can lead to cardiovascular disease (more commonly called heart disease), chest pain and even a heart attack or heart failure ...
Chemical structure of sildenafil (Viagra), the prototypical PDE5 inhibitor. A phosphodiesterase type 5 inhibitor (PDE5 inhibitor) is a vasodilating drug that works by blocking the degradative action of cGMP-specific phosphodiesterase type 5 (PDE5) on cyclic GMP in the smooth muscle cells lining the blood vessels supplying various tissues.
Recent heart problems or heart failure A previous heart attack or cardiovascular event Like other medications, Viagra can cause drug interactions , including with medications such as alpha ...
Sildenafil (compound UK-92,480) was synthesized by a group of pharmaceutical chemists led by Simon Campbell [55] working at Pfizer's Sandwich, Kent, research facility in England. It was initially studied for use in hypertension (high blood pressure) and angina pectoris (a symptom of ischaemic heart disease). [56]
The lab discovered that inhibiting phosphodiesterase type 5A(PDE5A), which degraded cyclic guanosine onophosphate (cGMP) and was inhibited by the drug sildenafil (Viagra®), blunted heart contractility from adrenergic stimuli in animal and human hearts, [28] [29] [30] and when chronically administered to animals, it improved their heart ...
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