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Erythromelalgia; Erythromelalgia in left hand: Specialty: Oncology: Causes: There was a study done in 2013 where two Vietnamese patients were diagnosed with primary erythromelalgia. Patient A was a 33-year old female diagnosed with primary erythromelalgia at age 30 and suffered from burning and pain in her feet since she was 8 years old (Wu et ...
PEPD symptoms are reminiscent of primary erythromelalgia, as both result in flushing and episodic pain, though pain is typically present in the extremities for primary erythromelalgia. Both of these disorders have recently been shown to be allelic, both caused by mutations in the voltage-gated sodium channel Na V 1.7 encoded by the gene SCN9A .
[20] [21] Like primary erythromelalgia, PEPD is similarly the result of a gain-of-function mutation in the gene encoding the Na v 1.7 channel. [20] [21] The decreased inactivation caused by the mutation is cause of prolonged action potentials and repetitive firing. Such altered firing will cause increased pain sensation and increased ...
Mitchell's disease (erythromelalgia) is named after him. He also coined the term phantom limb during his study of an amputee. [6] Mitchell discovered and treated causalgia (today known as CRPS/RSD), a condition most often encountered by hand surgeons. Mitchell is considered the father of medical neurology and a pioneer of "evidence-based" or ...
Erythromelalgia: Voltage-gated sodium channel Generalized epilepsy with febrile seizures plus: Voltage-gated sodium channel Familial hemiplegic migraine: various Associated with one particular disabling form of fibromyalgia [4] Voltage-gated sodium channel Hyperkalemic periodic paralysis: Voltage-gated sodium channel Hypokalemic periodic paralysis
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