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Healthy people may not have many symptoms with methemoglobin levels below 15%. However, people with co-morbidities such as anemia , cardiovascular disease, lung disease, sepsis , or who have abnormal hemoglobin species (e.g. carboxyhemoglobin , sulfhemoglobinemia or sickle hemoglobin ) may experience moderate to severe symptoms at much lower ...
Anemia is the most common blood disorder, affecting about a fifth to a third of the global population. [1] [11] [12] [13] Iron-deficiency anemia is the most common cause of anemia worldwide, and affects nearly one billion people. [14] In 2013, anemia due to iron deficiency resulted in about 183,000 deaths – down from 213,000 deaths in 1990. [15]
Left: Hand of a person with severe anemia. Right: Hand of a person without anemia. A patient having thalassemia shows enlarged spleen. Iron overload: People with thalassemia can get an overload of iron in their bodies, either from the disease itself or from frequent blood transfusions.
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Iron-deficiency anemia affected about 1.48 billion people in 2015. [6] A lack of dietary iron is estimated to cause approximately half of all anemia cases globally. [12] Women and young children are most commonly affected. [3] In 2015, anemia due to iron deficiency resulted in about 54,000 deaths – down from 213,000 deaths in 1990. [7] [13]
Sideroblastic anemia, or sideroachrestic anemia, is a form of anemia in which the bone marrow produces ringed sideroblasts rather than healthy red blood cells (erythrocytes). [1] In sideroblastic anemia, the body has iron available but cannot incorporate it into hemoglobin , which red blood cells need in order to transport oxygen efficiently.
Myelophthisic anemia (also known as myelophthisis) is a severe kind of anemia found in some people with diseases that affect the bone marrow. Myelophthisis is the displacement of hemopoietic bone-marrow tissue into the peripheral blood, [51] either by fibrosis, tumors or granulomas. Neuroacanthocytosis: 29707: D054546
In approximately 2.7 to 5 percent of cases, autoimmune hemolytic anemia and ITP coexist, a condition referred to as Evans syndrome. [13] [14] Despite the destruction of platelets by splenic macrophages, the spleen is normally not enlarged. In fact, an enlarged spleen should lead to a search for other possible causes for the thrombocytopenia.