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  2. Mirvetuximab soravtansine - Wikipedia

    en.wikipedia.org/wiki/Mirvetuximab_soravtansine

    Participants were randomized (1:1) to receive mirvetuximab soravtansine-gynx 6 mg/kg (based on adjusted ideal body weight) as an intravenous infusion every 3 weeks or investigator’s choice of chemotherapy (paclitaxel, pegylated liposomal doxorubicin, or topotecan) until disease progression or unacceptable toxicity. [6]

  3. Ruthenium anti-cancer drugs - Wikipedia

    en.wikipedia.org/wiki/Ruthenium_anti-cancer_drugs

    Cancer cells generally contain a lower oxygen concentration as well as higher levels of glutathione and a lower pH than normal tissues creating a reducing environment. Upon entering cancer cells NAMI-A is activated by the reduction of Ru(III) to Ru(II) to form the active anti-cancer agent. [citation needed]

  4. Management of multiple sclerosis - Wikipedia

    en.wikipedia.org/wiki/Management_of_multiple...

    Mitoxantrone is an immunosuppressant also used in cancer chemotherapy which was approved for MS in the year 2000; [35] whereas natalizumab is a monoclonal antibody that was initially approved in 2004. [36] Both are given by intravenous infusion at monthly intervals in the case of natalizumab and every three months in the case of mitoxantrone ...

  5. Glutathione - Wikipedia

    en.wikipedia.org/wiki/Glutathione

    Glutathione (GSH, / ˌ ɡ l uː t ə ˈ θ aɪ oʊ n /) is an organic compound with the chemical formula HOCOCH(NH 2)CH 2 CH 2 CONHCH(CH 2 SH)CONHCH 2 COOH. It is an antioxidant in plants , animals , fungi , and some bacteria and archaea .

  6. Ciltacabtagene autoleucel - Wikipedia

    en.wikipedia.org/wiki/Ciltacabtagene_autoleucel

    The safety and efficacy of ciltacabtagene autoleucel were evaluated in CARTITUDE-1 (NCT03548207), an open label, multicenter clinical trial evaluating ciltacabtagene autoleucel in 97 participants with relapsed or refractory multiple myeloma who received at least three prior lines of therapy which included a proteasome inhibitor, an immunomodulatory agent, and an anti-CD38 monoclonal antibody ...

  7. FDA identifies recall of B. Braun Medical pump system ... - AOL

    www.aol.com/news/fda-identifies-recall-b-braun...

    There have been 51 complaints, one death related to this recall and one reported injury, the FDA said. The company has asked customers to not use the device for high-risk medications, and only use ...

  8. Chlorambucil - Wikipedia

    en.wikipedia.org/wiki/Chlorambucil

    A recent study has shown Chlorambucil to be detoxified by human glutathione transferase Pi (GST P1-1), an enzyme that is often found over-expressed in cancer tissues. [13] This is important since Chlorambucil, as an electrophile, is made less reactive by conjugation with glutathione, thereby making the drug less toxic to the cell.

  9. Sorafenib - Wikipedia

    en.wikipedia.org/wiki/Sorafenib

    Sorafenib, sold under the brand name Nexavar, [3] is a kinase inhibitor drug approved for the treatment of primary kidney cancer (advanced renal cell carcinoma), advanced primary liver cancer (hepatocellular carcinoma), FLT3-ITD positive AML and radioactive iodine resistant advanced thyroid carcinoma.

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