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[3] [2] [4] The modafinil analogues are of interest in the potential treatment of a condition involving the misuse of stimulant drugs (psychostimulant use disorder or PSUD), as drugs that help increase motivation (pro-motivational agents) to treat motivational disorders, [4] [5] [6] and for treatment of neurodegenerative diseases such as ...
Modafinil, sold under the brand name Provigil among others, is a central nervous system (CNS) stimulant and eugeroic (wakefulness promoter) medication used primarily to treat narcolepsy, [3] [8] [15] a sleep disorder characterized by excessive daytime sleepiness and sudden sleep attacks. [16]
RDS03-94, or RDS3-094, is an atypical dopamine reuptake inhibitor that was derived from the wakefulness-promoting agent modafinil. [1] [2] [3] [4]It has substantially higher affinity and potency in terms of dopamine transporter (DAT) inhibition than modafinil (K i = 39.4 nM vs. 8,160 nM) whilst retaining the atypical DAT blocker profile of modafinil.
Subsequently, more selective modafinil-derived DAT blockers, like JJC8-088 and JJC8-091, were developed. [1] [9] JJC8-088 has ~90-fold higher affinity for the DAT than JJC8-016 and ~2-fold lower affinity for the hERG. [9] Newer related modafinil analogues and DRIs with further reduced affinity for the hERG were also subsequently developed. [11]
The drug has been found to block the dopamine transporter (DAT) by 83%, to a greater extent than methylphenidate without unfavorable concomitant adrenergic effects. [8] The drug is an atypical DRI similarly to modafinil. [11] [1] [9] The affinities for the DAT of flmodafinil's enantiomers and modafinil have also been studied.
In 2021, about 1.6 million people ages 12 and up in the U.S. had a methamphetamine use disorder and 1.4 million had a cocaine use disorder, according to data from the Substance Abuse and Mental ...
Amphetamines are a type of stimulant drug that energizes the central nervous system. They are prescribed to treat conditions such as attention deficit hyperactivity disorder (ADHD) , narcolepsy ...
There has been interest in (S)-MK-26 as a potential treatment for depression, psychostimulant use disorder (PSUD), Alzheimer's disease, and aging-related disorders. [ 2 ] [ 4 ] [ 3 ] It was first described by 2022.
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