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Nickel allergy is also more prevalent in women (17.1%) than men (3%), possibly due to cultural norms related to jewelry and ear piercings and therefore increased exposure to nickel. [36] In order to investigate the current prevalence of nickel, Loma Linda University , Nickel Allergy Alliance, and Dermatitis Academy, [ 37 ] are conducting a self ...
Nickel allergy and allergies to mercury and chromium have long been recognised; gold, palladium, and cobalt have gotten attention more recently. [2] [3] There is often cross-sensitization, where a person allergic to one metal may become allergic to another, but monosensitization, reacting to just one metal, is also possible. [4]
A patch test (contact delayed hypersensitivity allergy test) [17] is a commonly used examination to determine the exact cause of an allergic contact dermatitis. According to the American Academy of Allergy, Asthma, and Immunology, "patch testing is the gold standard for contact allergen identification". [2]
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Allergy to nickel is a common cause of contact dermatitis, with roughly 10% of the population in Western Europe and North America being sensitive to nickel. [1] [2] [3] Initial sensitisation frequently occurs from jewellery such as ear studs and other body piercings, [3] and nickel allergy is more prevalent among women than men.
A patch test relies on the principle of a type IV hypersensitivity reaction.. The first step in becoming allergic is sensitization. When skin is exposed to an allergen, the antigen-presenting cells (APCs) – also known as Langerhans cell or Dermal Dendritic Cell – phagocytize the substance, break it down to smaller components and present them on their surface bound major histocompatibility ...