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The number of patients who discontinued taking tirzepatide also increased as the dosage increased, with patients taking 15 mg having a 25% discontinuation rate vs 5.1% for 5 mg patients and 11.1% for dulaglutide. [28] [clarification needed] To a slightly lesser extent, patients also reported reduced appetite. [27]
15 percent for those taking 5mg of tirzepatide. 19.5 percent for those taking 10mg of tirzepatide. 20.9 percent for those taking 15mg of tirzepatide. 3.1 percent for those on the placebo.
Tirzepatide (Mounjaro) Effectiveness for Weight Loss A 2023 systematic review and meta-analysis looked into 14 trials of tirzepatide on more than 11,000 people with type 2 diabetes.
While tirzepatide has been on the market to treat type 2 diabetes under the name Mounjaro, Zepbound was just FDA approved for weight loss and most health insurances don’t cover it as a result ...
Tirzepatide, a dual agonist of GLP-1 and GIP receptors, is approved for type 2 diabetes and obesity. With an average 20 percent weight loss at a high dosage, it appears to be more effective than GLP-1 mono agonists although there have been no head to head trials as of 2023. [1] [3]
[1] [2] In a Phase II trial, weight loss averaged -15.6 percent after 32 weeks, making CagriSema comparable in efficacy to tirzepatide. [3] [4] A future trial sponsored by Novo Nordisk is comparing tirzepatide and CagriSema head-to-head. [5] As of 2023, CagriSema is in a Phase III trial. [6]
A four-week supply of 2.5-milligram (mg) vials is $399, and a four-week supply of 5-mg vials is $529, less than half the list price of other GLP-1 medicines for obesity, according to Eli Lilly.
GLP-1 agonists such as tirzepatide, semaglutide, and liraglutide slow gastric emptying and also have neurologically driven effects on appetite. [14] It is unknown if GLP-1 agonists or dual/triple agonists of GLP-1 and/or the glucagon or GIP receptors act solely by reducing energy intake or if they also increase energy expenditure.