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Feline hypertrophic cardiomyopathy (HCM) is the most common heart disease in domestic cats; [69] [70] [71] the disease process and genetics are believed to be similar to the disease in humans. [72] In Maine Coon cats, HCM has been confirmed as an autosomal dominant inherited trait. [73] Numerous cat breeds have HCM as a problem in the breed. [74]
Genetics. Having genes associated with cardiovascular disease. Other risk factors for cardiovascular disease include: ... Hypertrophic cardiomyopathy doesn’t always need treatment, ...
H ypertrophic cardiomyopathy is the most common form of genetic heart disease worldwide. Researchers have estimated that up to 1 in 200 people have the condition, which is characterized by an ...
Hypertrophic cardiomyopathy (HCM) is a condition where some of the heart muscle becomes too thick, (a.k.a., hypertrophied, a typical diagnostic criterion is a 15 millimeters or greater left ...
However, not all mutations have the same potential for severe outcomes, and there is not yet a clear understanding of how these mutations (which affect the same myosin protein molecule) can lead to the dramatically different clinical characteristics and outcomes associated with hypertrophic cardiomyopathy (HCM) and dilated cardiomyopathy (DCM). [9]
[55] [56] MYBPC3 was thus the fourth gene for hypertrophic cardiomyopathy, following MYH7, encoding β-myosin heavy chain, TNNT2 and TPM1, encoding cardiac troponin T and α-tropomyosin, respectively, earmarking hypertrophic cardiomyopathy (HCM) as a disease of the sarcomere. Truncation mutations in MYBPC3 stand as the primary cause of HCM. [57]
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