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  2. Prophase - Wikipedia

    en.wikipedia.org/wiki/Prophase

    Prophase is the first stage of mitosis in animal cells, and the second stage of mitosis in plant cells. [10] At the start of prophase there are two identical copies of each chromosome in the cell due to replication in interphase. These copies are referred to as sister chromatids and are attached by DNA element called the centromere. [11]

  3. Meiotic recombination checkpoint - Wikipedia

    en.wikipedia.org/wiki/Meiotic_recombination...

    Wee1 activity is high in early prophase I and the accumulation of Cdc25 activates M-Cdk by direct phosphorylation and marking Wee1 to be degraded. Meiotic recombination may begin with a double-strand break, either induced by Spo11 [2] or by other endogenous or exogenous causes of DNA damage. These DNA breaks must be repaired before metaphase I ...

  4. Replication timing - Wikipedia

    en.wikipedia.org/wiki/Replication_timing

    [11] [12] In all multi-cellular organisms where it has been measured, early replication takes place in the interior of the nucleus and the chromatin around the periphery is replicated later. Recently developed methods to measure the points where different parts of chromosomes touch each other are almost perfectly aligned to when they replicate ...

  5. Leptotene stage - Wikipedia

    en.wikipedia.org/wiki/Leptotene_stage

    The leptotene stage, also known as leptonema, is the first of five substages of prophase I during meiosis, the specialized cell division that reduces the chromosome number by half to produce haploid gametes in sexually reproducing organisms.

  6. Cell cycle checkpoint - Wikipedia

    en.wikipedia.org/wiki/Cell_cycle_checkpoint

    During early G1, there are three transcriptional repressors, known as pocket proteins, that bind to E2F transcription factors. The E2F gene family is a group of transcription factors that target many genes that are important for control of the cell cycle, including cyclins, CDKs, checkpoint regulators, and DNA repair proteins.

  7. Preprophase - Wikipedia

    en.wikipedia.org/wiki/Preprophase

    At the beginning of preprophase, the cortical microtubules of a plant cell disappear and aggregate into a dense ring underneath the plasma membrane. This preprophase band runs around the equatorial plane of the future mitotic spindle and marks the plane of cell division and future fusion site for the cell plate.

  8. Timeline of scientific experiments - Wikipedia

    en.wikipedia.org/wiki/Timeline_of_scientific...

    1021 – Ibn al-Haytham (Alhacen) pioneers the experimental scientific method and experimental physics in his Book of Optics, where he devises the first scientific experiments on optics, including the first use of the camera obscura to prove that light travels in straight lines and the first experimental proof that visual perception is caused ...

  9. Induced cell cycle arrest - Wikipedia

    en.wikipedia.org/wiki/Induced_cell_cycle_arrest

    In some experiments, a researcher may want to control and synchronize the time when a group of cells progress to the next phase of the cell cycle. [5] The cells can be induced to arrest as they arrive (at different time points) at a certain phase, so that when the arrest is lifted (for instance, rescuing cell cycle progression by introducing another chemical) all the cells resume cell cycle ...