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The Pathway Interaction Database (PID) is a free biomedical database of human cellular signaling pathways. [1] The database contains information about the molecular interactions and reactions that take place in cells, with a particular focus on processes that might be relevant to cancer research and treatment.
Three Wnt signaling pathways have been characterized: the canonical Wnt pathway, the noncanonical planar cell polarity pathway, and the noncanonical Wnt/calcium pathway. All three pathways are activated by the binding of a Wnt-protein ligand to a Frizzled family receptor , which passes the biological signal to the Dishevelled protein inside the ...
The New England News Collaborative (NENC) is a 10-station consortium of public media newsrooms located throughout New England. [1] NENC produced NEXT, a show about New England with WNPR. The final episode of the show was broadcast on May 27, 2021. [2] NENC was formed with a grant from the Corporation for Public Broadcasting in 2016. [3]
In cell biology, there are a multitude of signalling pathways. Cell signalling is part of the molecular biology system that controls and coordinates the actions of cells. Akt/PKB signalling pathway
Non-homologous end joining (NHEJ) is a pathway that repairs double-strand breaks in DNA. It is called "non-homologous" because the break ends are directly ligated without the need for a homologous template, in contrast to homology directed repair (HDR), which requires a homologous sequence to guide repair.
The Notch signaling pathway is a highly conserved cell signaling system present in most animals. [1] Mammals possess four different notch receptors , referred to as NOTCH1 , NOTCH2 , NOTCH3 , and NOTCH4 . [ 2 ]
The upstream signaling pathway is triggered by the binding of a signaling molecule, a ligand, to a receiving molecule, a receptor. Receptors and ligands exist in many different forms, and only recognize/bond to particular molecules. Upstream extracellular signaling transduce a variety of intracellular cascades. [1]
The mevalonate pathway (MVA pathway or HMG-CoA reductase pathway) and the MEP pathway are metabolic pathways for the biosynthesis of isoprenoid precursors: IPP and DMAPP. . Whereas plants use both MVA and MEP pathway, most organisms only use one of the pathways for the biosynthesis of isoprenoid precurs