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  2. Mechanism of action of aspirin - Wikipedia

    en.wikipedia.org/wiki/Mechanism_of_action_of_aspirin

    Aspirin acts as an acetylating agent where an acetyl group is covalently attached to a serine residue in the active site of the COX enzyme. [1] This makes aspirin different from other NSAIDs (such as diclofenac and ibuprofen), which are reversible inhibitors; aspirin creates an allosteric change in the structure of the COX enzyme. [2]

  3. Peripheral artery disease - Wikipedia

    en.wikipedia.org/wiki/Peripheral_artery_disease

    The illustration shows how PAD can affect arteries in the legs. Figure A shows a normal artery with normal blood flow. The inset image shows a cross-section of the normal artery. Figure B shows an artery with plaque buildup that is partially blocking blood flow. The inset image shows a cross-section of the narrowed artery.

  4. Peripheral vascular system - Wikipedia

    en.wikipedia.org/wiki/Peripheral_vascular_system

    The peripheral vascular system is the part of the circulatory system that consists of the veins and arteries not in the chest or abdomen (i.e. in the arms, hands, legs and feet). [1] [2] The peripheral arteries supply oxygenated blood to the body, and the peripheral veins lead deoxygenated blood from the capillaries in the extremities back to ...

  5. This blood condition is the result of weak blood flow. How it ...

    www.aol.com/blood-condition-result-weak-blood...

    Extra blood pooling in the legs can lead to leg pain, swelling, cramping/charley horse, skin discoloration or change in skin texture (e.g., "leathery" skin development), varicose veins (affecting ...

  6. Edema - Wikipedia

    en.wikipedia.org/wiki/Edema

    It is a combination venous/lymphatic disorder that originates in defective "leaky" veins that allows the blood to back flow (venous reflux), slowing the return of the blood to the heart (venous stasis). The venous pressure in the legs changes dramatically while standing compared to lying down.

  7. Thromboangiitis obliterans - Wikipedia

    en.wikipedia.org/wiki/Thromboangiitis_obliterans

    It reduces vasoconstriction and increases blood flow to limb. It aids in healing and giving relief from pain of ischemic ulcers. [1] Bypass can sometimes be helpful in treating limbs with poor perfusion secondary to this disease. Use of vascular growth factor and stem cell injections have been showing promise in clinical studies.

  8. Vasoconstriction - Wikipedia

    en.wikipedia.org/wiki/Vasoconstriction

    The process is the opposite of vasodilation, the widening of blood vessels. The process is particularly important in controlling hemorrhage and reducing acute blood loss. When blood vessels constrict, the flow of blood is restricted or decreased, thus retaining body heat or increasing vascular resistance.

  9. Atherosclerosis - Wikipedia

    en.wikipedia.org/wiki/Atherosclerosis

    The result is the formation of a thrombus (blood clot) overlying the atheroma, which obstructs blood flow acutely. With the obstruction of blood flow, downstream tissues are starved of oxygen and nutrients. If this is the myocardium (heart muscle) angina (cardiac chest pain) or myocardial infarction (heart attack) develops. [citation needed]