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Molecular classification of breast cancer from mRNA expression profiles. DNA microarrays have compared normal cells to breast cancer cells and found differences in the expression of hundreds of genes. Although the significance of many of those genetic differences is unknown, independent analyses by different research groups has found that ...
Capivasertib, sold under the brand name Truqap, is an anti-cancer medication used for the treatment of breast cancer. [4] [7] It is taken by mouth.[4]The most common adverse reactions include diarrhea, cutaneous adverse reactions, increased random glucose, decreased lymphocytes, decreased hemoglobin, increased fasting glucose, nausea, fatigue, decreased leukocytes, increased triglycerides ...
Alpelisib is indicated in combination with fulvestrant for the treatment of postmenopausal women, and men, with hormone receptor (HR)-positive, human epidermal growth factor receptor 2 (HER2)-negative, PIK3CA-mutated, advanced or metastatic breast cancer as detected by an FDA-approved test following progression on or after an endocrine-based regimen.
The study, which looked at data from 2004 to 2021, found that advanced breast cancer rates have risen among women of all ages, with the sharpest increases in young women aged 20 to 39, and women ...
Patient with locally advanced invasive breast cancer may be offered neoadjuvant systemic therapy and evaluated for tumor response prior to surgery, radiation, and adjuvant therapy. [31] Prophylactic treatment may be an option for those with genetic predisposition to breast cancer.
Sacituzumab govitecan is indicated for the treatment of adults with metastatic triple-negative breast cancer who received at least two prior therapies for metastatic disease; [11] people with unresectable locally advanced or metastatic triple-negative breast cancer (mTNBC) who have received two or more prior systemic therapies, at least one of them for metastatic disease; [14] and for people ...
Talazoparib is indicated for the treatment of breast cancer and prostate cancer. [6] [8] It is indicated for the treatment of people with deleterious or suspected deleterious germline BRCA-mutated (gBRCAm), HER2‑negative locally advanced or metastatic breast cancer; [12] and, in combination with enzalutamide, for homologous recombination repair (HRR) gene-mutated metastatic castration ...
It is being investigated as a possible cancer treatment. [3] It has been shown to be toxic to Waldenström's macroglobulinemia cells. [4] It was the first PI3K inhibitor to enter clinical trials, in 2006. [5] A phase IB/II clinical trial for locally advanced or metastatic HER2 negative breast cancer has completed. [6]
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