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The mouse HoxA cluster shown here has 11 paralogous genes (2 are missing). [39] Paralogous genes can shape the structure of whole genomes and thus explain genome evolution to a large extent. Examples include the Homeobox genes in animals. These genes not only underwent gene duplications within chromosomes but also whole genome duplications. As ...
Homologous sequences are paralogous if they were created by a duplication event within the genome. For gene duplication events, if a gene in an organism is duplicated, the two copies are paralogous. They can shape the structure of whole genomes and thus explain genome evolution to a large extent. Examples include the Homeobox genes in animals.
Gene conversion is the process by which one DNA sequence replaces a homologous sequence such that the sequences become identical after the conversion. [1] Gene conversion can be either allelic, meaning that one allele of the same gene replaces another allele, or ectopic, meaning that one paralogous DNA sequence converts another.
Paralogous sequences are separated by gene cloning (gene duplication): if a particular gene in the genome is copied, then the copy of the two sequences is paralogous to the original gene. A pair of orthologous sequences is called orthologous pairs (orthologs), a pair of paralogous sequence is called collateral pairs (paralogs).
Genes that have shared ancestry are homologs. If a speciation event occurs and one gene ends up in two different species the genes are now orthologous. If a gene is duplicated within the a singular species then it is a paralog. A molecular clock can be used to estimate when these events occurred. [18] Mammalian Phylogeny
In evolutionary biology, conserved sequences are identical or similar sequences in nucleic acids (DNA and RNA) or proteins across species (orthologous sequences), or within a genome (paralogous sequences), or between donor and receptor taxa (xenologous sequences). Conservation indicates that a sequence has been maintained by natural selection.
HOX genes control the regulation and development of many key structures in the body, such as somites, which form the vertebrae and ribs, the dermis of the dorsal skin, the skeletal muscles of the back, and the skeletal muscles of the body wall and limbs. HOX genes help differentiate somite cells into more specific identities and direct them to ...
The gap genes work to activate the pair-rule genes. Each pair-rule gene is expressed in seven stripes as a result of the combined effect of the gap genes and interactions between the other pair-rule genes. The pair-rule genes can be divided into two classes: the primary pair-rule genes and the secondary pair-rule genes.