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In vitro at high experimental doses, polyphenols may affect cell-to-cell signaling, receptor sensitivity, inflammatory enzyme activity or gene regulation. [3] [4] None of these hypothetical effects has been confirmed in humans by high-quality clinical research, as of 2020. [1]
Polyphenols in plant-based foods may trigger gastrointestinal hormones that could help reduce a person's risk for both obesity and type 2 diabetes, new research indicates.
Polyphenols are a large, diverse group of compounds, making it difficult to determine their biological effects. [56] They are not considered nutrients, as they are not used for growth, survival or reproduction, nor do they provide dietary energy. Therefore, they do not have recommended daily intake levels, as exist for vitamins, minerals, and ...
The amino acid tryptophan may also help, but more research is required to confirm its effects. The Mediterranean diet primarily includes unsaturated fats, with olive oil being a big fat source.
Researchers say there is evidence that orange peel benefits the gut microbiome in several ways: The fiber from the peels supports the growth of beneficial microorganisms in the intestines.
Adverse effects resulted mainly from long-term use (weeks or longer) and daily doses of 1000 mg or higher, causing nausea, stomach pain, flatulence, and diarrhea. [6] A review of 136 patients in seven studies who were given more than 500 mg for a month showed 25 cases of diarrhea, 8 cases of abdominal pain, 7 cases of nausea, and 5 cases of ...
To begin with, green tea contains polyphenols, which are considered a type of antioxidant, says Coleen Wysocki, M.S., RDN, owner of Zest Nutrition. Although there are thousands of polyphenols ...
Clinical studies investigating the relationship between flavonoid consumption and cancer prevention or development are conflicting for most types of cancer, probably because most human studies have weak designs, such as a small sample size. [1] [30] There is little evidence to indicate that dietary flavonoids affect human cancer risk in general ...
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