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Medically unexplained physical symptoms (MUPS or MUS) are symptoms for which a treating physician or other healthcare providers have found no medical cause, or whose cause remains contested. [1] In its strictest sense, the term simply means that the cause for the symptoms is unknown or disputed—there is no scientific consensus .
Several countries, including Australia [17] and the United Kingdom, have authored clinical guidelines that define ME/CFS based on some or all of the available diagnostic criteria. The 2021 UK NICE guideline requires all of the following symptoms: Debilitating fatigue; Post-exertional malaise; Unrefreshing and/or disturbed sleep; Cognitive ...
Burning mouth syndrome (BMS) is a burning, tingling or scalding sensation in the mouth, lasting for at least four to six months, with no underlying known dental or medical cause. [ 3 ] [ 7 ] No related signs of disease are found in the mouth. [ 3 ]
[10]: 16–17 Symptoms must be present at least half of the time, and be of moderate severity or worse; previous criteria just required symptoms to be present. [29]: 14 In 2021, NICE revised its criteria based on the IOM criteria. The updated criteria require fatigue, PEM, non-restorative sleep, and cognitive difficulties persisting for at ...
ICF differs from other forms of chronic fatigue since it is unexplained rather than linked to a medical or psychological illness (for example, diabetes or depression). [6] This means that ICF patients have reduced treatment options: there is no underlying disease or known cause that could be treated in order to reduce the degree of fatigue ...
An example of such a diagnosis is "fever of unknown origin": to explain the cause of elevated temperature the most common causes of unexplained fever (infection, neoplasm, or collagen vascular disease) must be ruled out. Other examples include: Fibromyalgia [9] Adult-onset Still's disease [10] Behçet's disease [11] Bell's palsy [12]
In 2016, the American Academy of Pediatrics (AAP) published a clinical practice guideling recommending the replacement of ALTE with a new term, brief resolved unexplained event (BRUE). [2] The guidelines state that the term ALTE is still applicable with key differences between ALTE and BRUE .
[2] [3] [4] In addition, Zijlema et al. (2013) [2] reviewed 99 scientific publications which presented 40 instruments designed to assess somatic symptoms, somatization, or medically unexplained symptoms. They conclude that a valid measure of somatic symptom burden should include items about "cardiopulmonary (including autonomic symptoms ...