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Reference ranges (reference intervals) for blood tests are sets of values used by a health professional to interpret a set of medical test results from blood samples. Reference ranges for blood tests are studied within the field of clinical chemistry (also known as "clinical biochemistry", "chemical pathology" or "pure blood chemistry"), the ...
The MammaPrint gene pattern is a commercial-stage 70-gene panel marketed by Agendia, [74] that was developed in patients under age 55 years who had lymph node negative breast cancers. [72] The commercial test is marketed for use in breast cancer irrespective of estrogen receptor (ER) status. [72]
Neu is so named because it was derived from a rodent glioblastoma cell line, a type of neural tumor. ErbB-2 was named for its similarity to ErbB (avian erythroblastosis oncogene B), the oncogene later found to code for EGFR. Molecular cloning of the gene showed that HER2, Neu, and ErbB-2 are all encoded by the same orthologs. [10]
Triple-negative breast cancer (TNBC) is any breast cancer that either lacks or shows low levels of estrogen receptor (ER), progesterone receptor (PR) and human epidermal growth factor receptor 2 (HER2) overexpression and/or gene amplification (i.e. the tumor is negative on all three tests giving the name triple-negative). [1]
adult male, avg. (range) 5.2 (4.6-6.2) × 10 9: adult female, avg. (range) 4.6 (4.2-5.4) × 10 9: children, varies with age 4.5-5.1 × 10 9: reticulocytes 25-75 × 10 6: Erythropoietin: adult, normal 0.5-2.5 × 10 −10: pregnant 2.7-6.2 × 10 −10: hypoxia or anemia 0.8-8.0 × 10 −8: Estradiol (E2) male 8-36 × 10 −12: female, follicular ...
The epidermal growth factor receptor is a member of the ErbB family of receptors, a subfamily of four closely related receptor tyrosine kinases: EGFR (ErbB-1), HER2/neu (ErbB-2), Her 3 (ErbB-3) and Her 4 (ErbB-4). In many cancer types, mutations affecting EGFR expression or activity could result in cancer. [6]
The standard definition of a reference range for a particular measurement is defined as the interval between which 95% of values of a reference population fall into, in such a way that 2.5% of the time a value will be less than the lower limit of this interval, and 2.5% of the time it will be larger than the upper limit of this interval, whatever the distribution of these values.
The stated normal range for human blood counts varies between laboratories, but a neutrophil count of 2.5–7.5 × 10 9 /L is a standard normal range. People of African and Middle Eastern descent may have lower counts, which are still normal. [17] A report may divide neutrophils into segmented neutrophils and bands.
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