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Antiarrhythmic agents, also known as cardiac dysrhythmia medications, are a class of drugs that are used to suppress abnormally fast rhythms (tachycardias), such as atrial fibrillation, supraventricular tachycardia and ventricular tachycardia.
Ibutilide is a Class III antiarrhythmic agent that is indicated for acute cardioconversion of atrial fibrillation and atrial flutter of a recent onset to sinus rhythm. It exerts its antiarrhythmic effect by induction of slow inward sodium current, which prolongs action potential and refractory period of myocardial cells.
Electrocardiographic image depicting atrial fibrillation (top, red arrow) and normal heart rhythm (bottom) Main article: Holiday heart syndrome Holiday heart syndrome , also known as alcohol-induced atrial arrhythmias, is a syndrome defined by an irregular heartbeat and palpitations [ 132 ] associated with high levels of ethanol consumption.
Atrial fibrillation is associated with an increased risk of heart failure, dementia, and stroke. [3] [12] It is a type of supraventricular tachycardia. [14] Atrial fibrillation frequently results from bursts of tachycardia that originate in muscle bundles extending from the atrium to the pulmonary veins. [15]
Flecainide has high bioavailability after an oral dose, [28] meaning that most of the drug that is ingested will enter the systemic blood stream. Peak serum concentrations can be seen 1 to 6 hours after ingestion of an oral dose. While the plasma half-life is about 20 hours, it is quite variable, and can range from 12 to 27 hours. [29]
A rapid, irregular rhythm might be due to atrial fibrillation, atrial flutter, or tachycardia with a variable block. [1] Supraventricular and ventricular tachycardias often cause sudden palpitations. They start and stop quickly. If someone can stop their palpitations with the Valsalva maneuver it may indicate SVT. [1]
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