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  2. Mouse models of breast cancer metastasis - Wikipedia

    en.wikipedia.org/wiki/Mouse_models_of_breast...

    Breast cancer metastatic mouse models are experimental approaches in which mice are genetically manipulated to develop a mammary tumor leading to distant focal lesions of mammary epithelium created by metastasis. Mammary cancers in mice can be caused by genetic mutations that have been identified in human cancer. This means models can be ...

  3. Mouse Models of Human Cancer database - Wikipedia

    en.wikipedia.org/wiki/Mouse_Models_of_Human...

    MMHCdb allows researchers to search for PDX models by such parameters as cancer site, diagnosis, genomic properties of the engrafted human tumor, and model treatment response. Fig. 3 shows the output of a search for PDX models whose engrafted tumors have amplified KRAS, the TP53 A159V mutation, a deletion of the ALB gene, and high KIT expression.

  4. Patient derived xenograft - Wikipedia

    en.wikipedia.org/wiki/Patient_derived_xenograft

    Patient derived xenografts (PDX) are models of cancer where the tissue or cells from a patient's tumor are implanted into an immunodeficient or humanized mouse. [1] It is a form of xenotransplantation. PDX models are used to create an environment that allows for the continued growth of cancer after its removal from a patient.

  5. Humanized mouse - Wikipedia

    en.wikipedia.org/wiki/Humanized_mouse

    [27] [28] Humanized mouse models for studying cancers of various organs have been designed. A mouse model for the study of breast cancer has been generated by the intrahepatic engraftment of SK-BR-3 cells in NSG mice. [29]

  6. NSG mouse - Wikipedia

    en.wikipedia.org/wiki/NSG_mouse

    A highly sensitive platform for studying epithelial [12] and cancer stem cells. [13] Establishing a functional, humanized immune system from engrafted human hematopoietic stem cells [14] [15] and progenitors. [16] Humanized models for studying human-specific infectious diseases like HIV, [17] Epstein Barr virus, [18] malaria, [19] and Dengue fever.

  7. Severe combined immunodeficient mice - Wikipedia

    en.wikipedia.org/wiki/Severe_combined_immuno...

    Prior to the use of humanized SCID mice, ape models were used to study HIV due to their genetic similarity to humans. However, due to the endangered status of chimps, the cost of maintaining them, and the slight differences between human and chimp interactions with HIV, humanized mice have been accepted as a more effective model organism for ...

  8. 4T1 - Wikipedia

    en.wikipedia.org/wiki/4T1

    4T1 is a breast cancer cell line derived from the mammary gland tissue of a mouse BALB/c strain. [1] 4T1 cells are epithelial and are resistant to 6-thioguanine. [1] In preclinical research, 4T1 cells have been used to study breast cancer metastasis as they can metastasize to the lung, liver, lymph nodes, brain and bone.

  9. C57BL/6 - Wikipedia

    en.wikipedia.org/wiki/C57BL/6

    It is the most widely used "genetic background" for genetically modified mice for use as models of human disease. They are the most widely used and best-selling mouse strain due to the availability of congenic strains, easy breeding, and robustness. [1] The median lifespan of C57BL/6 mice is 27–29 months and the maximum lifespan is about 36 ...

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