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The crystal structure of myelin oligodendrocyte glycoprotein was determined by x-ray diffraction at a resolution of 1.45 Angstroms, using protein from the Norway rat. This protein is 139 residues long, and is a member of the immunoglobulin superfamily. [13]
Serum anti-myelin oligodendrocyte glycoprotein antibodies are present in up to half of patients with an acquired demyelinating syndrome and have been described in association with a range of phenotypic presentations, including acute disseminated encephalomyelitis, optic neuritis, transverse myelitis, and neuromyelitis optica. [2]
18377 Ensembl n/a ENSMUSG00000049612 UniProt P23515 Q63912 RefSeq (mRNA) NM_002544 NM_019409 RefSeq (protein) NP_002535 NP_062282 Location (UCSC) n/a Chr 11: 79.39 – 79.39 Mb PubMed search Wikidata View/Edit Human View/Edit Mouse Oligodendrocyte-myelin glycoprotein is a protein that in humans is encoded by the OMG gene. See also Oligodendrocyte Myelin Glycoprotein References ^ a b c GRCm38 ...
Protein content includes myelin basic protein (MBP), [21] which is abundant in the CNS where it plays a critical, non-redundant role in formation of compact myelin; myelin oligodendrocyte glycoprotein (MOG), [22] which is specific to the CNS; and proteolipid protein (PLP), [23] which is the most abundant protein in CNS myelin, but only a minor ...
Myelin-associated glycoprotein (MAG, Siglec-4) is a type 1 transmembrane protein glycoprotein localized in periaxonal Schwann cell and oligodendrocyte membranes, where it plays a role in glial-axonal interactions.
EAE can be induced in a number of species, including mice, rats, guinea pigs, rabbits and primates. The most commonly used antigens in rodents are spinal cord homogenate (SCH), purified myelin, myelin protein such as MBP, PLP, and MOG, or peptides of these proteins, all resulting in distinct models with different disease characteristics regarding both immunology and pathology.
The second most frequent autoantibody in NMO is MOG-IgG, which targets myelin oligodendrocyte glycoprotein (MOG). MOG is an integral membrane glycoprotein found on the surface of oligodendrocytes and the outermost surface of myelin sheaths. [1] Its function is not entirely known. [1]
The three major myelin-associated inhibitory factors are Nogo, oligodendrocyte myelin glycoprotein, and myelin-associated glycoprotein which all share this trimolecular receptor complex. The inhibitory action is achieved through RhoA - GTP upregulation in response to the presence of MOG , MAG or Nogo-66 in the central nervous system. [ 12 ]
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