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  2. DNA replication - Wikipedia

    en.wikipedia.org/wiki/DNA_replication

    Within eukaryotes, DNA replication is controlled within the context of the cell cycle. As the cell grows and divides, it progresses through stages in the cell cycle; DNA replication takes place during the S phase (synthesis phase). The progress of the eukaryotic cell through the cycle is controlled by cell cycle checkpoints.

  3. Eukaryotic DNA replication - Wikipedia

    en.wikipedia.org/wiki/Eukaryotic_DNA_replication

    In bacterial DNA replication, regulation focuses on the binding of the DnaA initiator protein to the DNA, with initiation of replication occurring multiple times during one cell cycle. [93] Both prokaryotic and eukaryotic DNA use ATP binding and hydrolysis to direct helicase loading and in both cases the helicase is loaded in the inactive form.

  4. S phase - Wikipedia

    en.wikipedia.org/wiki/S_phase

    Detection of DNA damage induces activation of three canonical S-phase "checkpoint pathways" that delay or arrest further cell cycle progression: [12] The Replication Checkpoint detects stalled replication forks by integrating signals from RPA, ATR Interacting Protein (ATRIP), and RAD17. [12]

  5. Helicase - Wikipedia

    en.wikipedia.org/wiki/Helicase

    RecQ helicase Sgs1 is missing in yeast cells, making them useful models for comprehending human cell abnormalities and the RecQ helicase function. [52] The RecQ helicase family member, RECQ1, is connected to a small number of uncommon genetic cancer disorders in individuals. It participates in transcription, the cell cycle, and DNA repair.

  6. Control of chromosome duplication - Wikipedia

    en.wikipedia.org/wiki/Control_of_chromosome...

    In cell biology, eukaryotes possess a regulatory system that ensures that DNA replication occurs only once per cell cycle. A key feature of the DNA replication mechanism in eukaryotes is that it is designed to replicate relatively large genomes rapidly and with high fidelity. Replication is initiated at multiple origins of replication on ...

  7. Minichromosome maintenance - Wikipedia

    en.wikipedia.org/wiki/Minichromosome_Maintenance

    The minichromosome maintenance protein complex (MCM) is a DNA helicase essential for genomic DNA replication. Eukaryotic MCM consists of six gene products, Mcm2–7, which form a heterohexamer. [1] [2] As a critical protein for cell division, MCM is also the target of various checkpoint pathways, such as the S-phase entry and S-phase arrest ...

  8. Cell cycle - Wikipedia

    en.wikipedia.org/wiki/Cell_cycle

    The cell cycle, or cell-division cycle, is the sequential series of events that take place in a cell that causes it to divide into two daughter cells. These events include the growth of the cell, duplication of its DNA ( DNA replication ) and some of its organelles , and subsequently the partitioning of its cytoplasm, chromosomes and other ...

  9. DNA re-replication - Wikipedia

    en.wikipedia.org/wiki/DNA_re-replication

    DNA re-replication (or simply rereplication) is an undesirable and possibly fatal occurrence in eukaryotic cells in which the genome is replicated more than once per cell cycle. [1] Rereplication is believed to lead to genomic instability and has been implicated in the pathologies of a variety of human cancers . [ 2 ]