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It is not recommended in people with myasthenia gravis or other neuromuscular disorders. [4] Streptomycin is an aminoglycoside. [3] It works by blocking the ability of 30S ribosomal subunits to make proteins, which results in bacterial death. [3] Albert Schatz first isolated streptomycin in 1943 from Streptomyces griseus.
Elizabeth Bugie Gregory (October 5, 1920 – April 10, 2001) was an American biochemist who co-discovered Streptomycin, the first antibiotic against Mycobacterium tuberculosis in Selman Waksman laboratory at Rutgers University. [1]
Selman Abraham Waksman (July 22, 1888 – August 16, 1973) was a Jewish American inventor, Nobel Prize laureate, biochemist and microbiologist whose research into the decomposition of organisms that live in soil enabled the discovery of streptomycin and several other antibiotics.
Albert Israel Schatz (2 February 1920 – 17 January 2005) was an American microbiologist and academic who discovered streptomycin, [1] the first antibiotic known to be effective for the treatment of tuberculosis. [2]
There were 59 people who received the prize in the first 50 years of the last century, while 113 individuals received it between 1951 and 2000. This increase could be attributed to the rise of the international scientific community after World War II, resulting in more persons being responsible for the discovery, and nominated for, a particular ...
The discovery of streptomycin, an antituberculosis antibiotic, earned Selman Waksman the Nobel Prize in 1952. [19] The award was not without controversy, since it excluded the nomination of Albert Schatz , who is now recognized as one of the major co-inventors of streptomycin.
Parke-Davis's team of Dr. Rebstock and her team consisting of John Controulis, Harry Crooks, and Quentin Bartz discovered that greater chemical stability could be achieved through catalytic hydrogenation of streptomycin, and this new compound was named dihydrostreptomycin. This discovery was simultaneously made by a team at Merck & Co.
Tetracyclines are generally used in the treatment of infections of the urinary tract, respiratory tract, and the intestines and are also used in the treatment of chlamydia, especially in patients allergic to β-lactams and macrolides; however, their use for these indications is less popular than it once was due to widespread development of resistance in the causative organisms.