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The side effects of cyproterone acetate (CPA), a steroidal antiandrogen and progestin, including its frequent and rare side effects, have been studied and characterized.It is generally well-tolerated and has a mild side-effect profile, regardless of dosage, when it used as a progestin or antiandrogen in combination with an estrogen such as ethinylestradiol or estradiol valerate in women.
Prostate cancer in men; Androgen-dependent skin and hair conditions like acne, hirsutism, [4] seborrhea, and pattern hair loss (androgenic alopecia) in women; Hyperandrogenism, such as due to polycystic ovary syndrome or congenital adrenal hyperplasia, in women; As a component of hormone therapy for transgender women [5] Precocious puberty in ...
Cyproterone acetate (CPA), sold alone under the brand name Androcur or with ethinylestradiol under the brand names Diane or Diane-35 among others, is an antiandrogen and progestin medication used in the treatment of androgen-dependent conditions such as acne, excessive body hair growth, early puberty, and prostate cancer, as a component of feminizing hormone therapy for transgender individuals ...
Prostate cancer in men; Benign prostatic hyperplasia in men; Androgen-dependent skin and hair conditions like acne, hirsutism, [5] seborrhea, and pattern hair loss (androgenic alopecia) in women; Hyperandrogenism, such as due to polycystic ovary syndrome or congenital adrenal hyperplasia, in women; As a component of hormone therapy for ...
In any case, common side effects of antiandrogens in men include breast tenderness, breast enlargement, feminization, hot flashes, sexual dysfunction, infertility, and osteoporosis. In women, antiandrogens are much better tolerated , and antiandrogens that work only by directly blocking androgens are associated with minimal side effects.
In aged men with prostate cancer, continuous oral CPA therapy resulted in CPA levels of 132 ± 18 ng/mL at 25 mg/day, 246 ± 13 ng/mL at 50 mg/day, and 348 ± 23 ng/mL at 100 mg/day. [71] Similarly, in healthy young women, a single high oral dose of 100 mg CPA resulted in peak CPA levels of 255 ng/mL (612 nmol/L) within 2 to 3 hours.
Lavender oil has been used as a perfume, aromatherapy, and skin application, [8]: 184–186 but these uses have no clinical benefit. [9] Lavender oil is used in massage therapy as a way of inducing relaxation through direct skin contact, although allergic reactions may occur. [9]
Less common side effects of bicalutamide monotherapy in men include sexual dysfunction, depression, fatigue, weakness, and anemia. Bicalutamide is well tolerated and has few side effects in women. General side effects of bicalutamide that may occur in either sex include diarrhea, constipation, abdominal pain, nausea, dry skin, itching, and rash.