Search results
Results from the WOW.Com Content Network
A protein kinase inhibitor (PKI) is a type of enzyme inhibitor that blocks the action of one or more protein kinases. [1] Protein kinases are enzymes that phosphorylate (add a phosphate, or PO 4, group) to a protein and can modulate its function. [2] The phosphate groups are usually added to serine, threonine, or tyrosine amino acids on the
cAMP-dependent protein kinase inhibitor gamma is a protein that in humans is encoded by the PKIG gene. [5] [6] The protein encoded by this gene is a member of the cAMP-dependent protein kinase (PKA) inhibitor family. Studies of a similar protein in mice suggest that this protein acts as a potent competitive PKA inhibitor, and is a predominant ...
9451 13666 Ensembl ENSG00000172071 ENSMUSG00000031668 UniProt Q9NZJ5 Q9Z2B5 RefSeq (mRNA) NM_001313915 NM_004836 NM_010121 NM_001313918 RefSeq (protein) NP_001300844 NP_004827 NP_001300847 NP_034251 Location (UCSC) Chr 2: 88.56 – 88.69 Mb Chr 6: 70.82 – 70.88 Mb PubMed search Wikidata View/Edit Human View/Edit Mouse Eukaryotic translation initiation factor 2-alpha kinase 3, also known as ...
The protein encoded by this gene is a member of the cAMP-dependent protein kinase inhibitor family. This protein was demonstrated to interact with and inhibit the activities of both C alpha and C beta catalytic subunits of the PKA. Alternatively spliced transcript variants encoding the same protein have been reported. [6]
A protein kinase is a kinase which selectively modifies other proteins by covalently adding phosphates to them (phosphorylation) as opposed to kinases which modify lipids, carbohydrates, or other molecules.
Pages in category "Protein kinase inhibitors" The following 62 pages are in this category, out of 62 total. This list may not reflect recent changes. ...
Selumetinib is a kinase inhibitor, more specifically a selective inhibitor of the enzyme mitogen-activated protein kinase kinase (MAPK kinase or MEK) subtypes 1 and 2. These enzymes are part of the MAPK/ERK pathway, which regulates cell proliferation (i.e., growth and division) and is overly active in many types of cancer. [18]
Pemigatinib belongs to a group of medicines called protein kinase inhibitors. [10] It works by blocking enzymes known as protein kinases , particularly those that are part of receptors (targets) called fibroblast growth factor receptors (FGFRs). [ 10 ]