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AC almost always affects the lower lip and only rarely the upper lip, probably because the lower lip is more exposed to the sun. [7] In the unusual cases reported where it affects the upper lip, this may be due to upper lip prominence. [7] The commissures (corners of the mouth) are not usually involved. [2] [6]
Fluorouracil has been given systemically for anal, breast, colorectal, oesophageal, stomach, pancreatic and skin cancers (especially head and neck cancers). [12] It has also been given topically (on the skin) for actinic keratoses, skin cancers and Bowen's disease [12] (a type of cutaneous squamous-cell carcinoma), and as eye drops for treatment of ocular surface squamous neoplasia. [13]
For basal cell carcinoma excisions on the lower lip the wound can be covered with a keystone flap. A keystone flap is achieved by creating a flap below the defect and pulling it superiorly to cover the wound. This can be performed if there is enough skin laxity to cover the defect and adequate blood supply to the flap. [45]
Topical creams, such as 5-fluorouracil or imiquimod, may require daily application to affected skin areas over a typical time course of weeks. [ 13 ] Cryotherapy is frequently used for few and well-defined lesions, [ 14 ] but undesired skin lightening, or hypopigmentation, may occur at the treatment site. [ 15 ]
Psoriasis occurs when a person’s immune system incorrectly signals the skin cells to produce new cells too quickly. This causes an excess in skin cells that cause patches and scabs.
Psoralens are taken as pills (systemically) or can be applied directly to the skin, by soaking the skin in a solution that contains the psoralens. They allow UVA energy to be effective at lower doses. When combined with exposure to the UVA in PUVA, psoralens are highly effective at clearing psoriasis and vitiligo. In the case of vitiligo, they ...
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