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Extranodal NK/T-cell lymphoma, nasal type occurs primarily in Asians and South Americans; it is comparatively uncommon in other areas. Affected patients (median age 50–60 years old; males predominate) most often (~80% of cases) present with nasal bleeding, upper airway obstruction, perforation of the hard palate, and/or disfiguring, necrotic lesions of the nasal cavity, nasopharynx ...
Date: 25 June 2021: Source: Image source: Takahara M, Kumai T, Kishibe K, Nagato T, Harabuchi Y (2021)."Extranodal NK/T-Cell Lymphoma, Nasal Type: Genetic, Biologic, and Clinical Aspects with a Central Focus on Epstein-Barr Virus Relation.
The disease is therefore now regarded as a NK/T cell malignancy, is grouped with other Epstein–Barr virus–associated lymphoproliferative diseases [4] and is classified by the World Health Organization (2017 update) as a manifestation of the well-defined disease, extranodal NK/T-cell lymphoma, nasal type (ENKTCL-NT).
Peripheral T-cell lymphoma refers to a group of T-cell lymphomas that develop away from the thymus [citation needed] or bone marrow. [1] Examples include: [2] Cutaneous T-cell lymphomas; Angioimmunoblastic T-cell lymphoma; Extranodal natural killer/T-cell lymphoma, nasal type; Enteropathy type T-cell lymphoma; Subcutaneous panniculitis-like T ...
The incidence of T-cell lymphoma are slightly higher in men than in women in all categories of race, [7] with cases increasing in frequency with age for most subtypes. [2] In Asia, T/NK-cell neoplasms are more common as a result of host factors and the higher prevalence of human T-cell leukemia virus-1 (HTLV1) and Epstein–Barr virus (EBV).
Certain lymphomas (extranodal NK/T-cell lymphoma, nasal type and type II enteropathy-associated T-cell lymphoma) can be mimicked by two benign diseases that involve the excessive proliferation of nonmalignant NK cells in the GI tract, natural killer cell enteropathy, a disease wherein NK cell infiltrative lesions occur in the intestine, colon ...
Enteropathy-associated T-cell lymphoma; Epstein–Barr virus–associated lymphoproliferative diseases; Epstein–Barr virus positive diffuse large B-cell lymphoma; Extranodal NK/T-cell lymphoma, nasal type
Anaplastic large cell lymphoma (ALCL) is a subtype of mature T-cell lymphoma involving T-cells or natural killer (NK) cells, representing 12% of patients. [9] It can be recognized by a constant expression of the tumour receptor necrosis factor CD30, a membrane protein expressed by activated T and B cells, in the cancer cells. [13]
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