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  2. DNA replication stress - Wikipedia

    en.wikipedia.org/wiki/DNA_replication_stress

    Replication stress and its consequences in mitosis. DNA replication stress refers to the state of a cell whose genome is exposed to various stresses. The events that contribute to replication stress occur during DNA replication, and can result in a stalled replication fork. [1] There are many events that contribute to replication stress ...

  3. Cell cycle checkpoint - Wikipedia

    en.wikipedia.org/wiki/Cell_cycle_checkpoint

    Similar to S Phase, G2 experiences a DNA damage checkpoint. The cell is once more examined for sites of DNA damage or incomplete replication, and the kinases ATR and ATM are recruited to damage sites. Activation of Chk1 and Chk2 also transpire, as well as p53 activation, to induce cell cycle arrest and halt progression into mitosis.

  4. Cell cycle - Wikipedia

    en.wikipedia.org/wiki/Cell_cycle

    The eukaryotic cell cycle consists of four distinct phases: G 1 phase, S phase (synthesis), G 2 phase (collectively known as interphase) and M phase (mitosis and cytokinesis). M phase is itself composed of two tightly coupled processes: mitosis, in which the cell's nucleus divides, and cytokinesis, in which the cell's cytoplasm and cell membrane divides forming two daughter cells.

  5. G2-M DNA damage checkpoint - Wikipedia

    en.wikipedia.org/wiki/G2-M_DNA_damage_checkpoint

    Steps of the cell cycle. The G 2-M checkpoint occurs between the G 2 and M phases. G2-M arrest. The G 2-M DNA damage checkpoint is an important cell cycle checkpoint in eukaryotic organisms that ensures that cells don't initiate mitosis until damaged or incompletely replicated DNA is sufficiently repaired.

  6. Mitosis - Wikipedia

    en.wikipedia.org/wiki/Mitosis

    The mitosis process in the cells of eukaryotic organisms follows a similar pattern, but with variations in three main details. "Closed" and "open" mitosis can be distinguished on the basis of nuclear envelope remaining intact or breaking down. An intermediate form with partial degradation of the nuclear envelope is called "semiopen" mitosis.

  7. Replication timing - Wikipedia

    en.wikipedia.org/wiki/Replication_timing

    The temporal order of replication of all the segments in the genome, called its replication-timing program, can now be easily measured in two different ways. [1] One way simply measures the amount of the different DNA sequences along the length of the chromosome per cell.

  8. RFK Jr set to face abortion, vaccine scrutiny in sit-downs ...

    www.aol.com/rfk-jr-set-face-abortion-090044444.html

    Robert F. Kennedy Jr. will be on Capitol Hill this week for a series of meetings with senators after being chosen by President-elect Donald Trump to head up the U.S. Department of Health and Human ...

  9. DNA repair - Wikipedia

    en.wikipedia.org/wiki/DNA_repair

    mismatch of bases, due to errors in DNA replication, in which the wrong DNA base is stitched into place in a newly forming DNA strand, or a DNA base is skipped over or mistakenly inserted. Monoadduct damage cause by change in single nitrogenous base of DNA; Di adduct damage; Damage caused by exogenous agents comes in many forms. Some examples are: