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  2. Pathophysiology of HIV/AIDS - Wikipedia

    en.wikipedia.org/wiki/Pathophysiology_of_HIV/AIDS

    Abortive HIV infection occurs due to slowing of reverse transcription promoting cytosolic DNA accumulation. This viral DNA is sensed by gamma-interferon-inducible protein 16 ( IFI16 ), [ 11 ] which produces an innate immune response against the virus by activating caspase 1 in IFI16 inflammasomes and inducing pyroptosis , a highly inflammatory ...

  3. HIV - Wikipedia

    en.wikipedia.org/wiki/HIV

    HIV-1 is more virulent and more infective than HIV-2, [20] and is the cause of the majority of HIV infections globally. The lower infectivity of HIV-2, compared to HIV-1, implies that fewer of those exposed to HIV-2 will be infected per exposure. Due to its relatively poor capacity for transmission, HIV-2 is largely confined to West Africa. [21]

  4. Coinfection - Wikipedia

    en.wikipedia.org/wiki/Coinfection

    However, network analysis of a food web of coinfection in humans suggests that there is greater potential for interactions via shared food sources than via the immune system. [7] A globally common coinfection involves tuberculosis and HIV. In some countries, up to 80% of tuberculosis patients are also HIV-positive. [8]

  5. Human viruses in water - Wikipedia

    en.wikipedia.org/wiki/Human_viruses_in_water

    Half of the hospital beds occupied in the world are related to the lack of safe drinking water. Unsafe water leads to the 88% of the global cases of diarrhea and 90% of the deaths of diarreaheal diseases in children under five years old. Most of these deaths occur in developing countries due to poverty and the high cost of safe water. [13]

  6. Pathogen transmission - Wikipedia

    en.wikipedia.org/wiki/Pathogen_transmission

    Fecal–oral transmission is primarily considered as an indirect contact route through contaminated food or water. However, it can also operate through direct contact with feces or contaminated body parts, such as through anal sex. [19] [20] It can also operate through droplet or airborne transmission through the toilet plume from contaminated ...

  7. HIV/AIDS - Wikipedia

    en.wikipedia.org/wiki/HIV/AIDS

    HIV is a retrovirus that primarily infects components of the human immune system such as CD4 + T cells, macrophages and dendritic cells. It directly and indirectly destroys CD4 + T cells. [88] HIV is a member of the genus Lentivirus, [89] part of the family Retroviridae. [90] Lentiviruses share many morphological and biological characteristics.

  8. Infection - Wikipedia

    en.wikipedia.org/wiki/Infection

    Vehicle transmission, transmission by an inanimate reservoir (food, water, soil). [32] Vertical transmission, directly from the mother to an embryo, fetus or baby during pregnancy or childbirth. It can occur as a result of a pre-existing infection or one acquired during pregnancy. Iatrogenic transmission, due to medical procedures such as ...

  9. Vertical transmission - Wikipedia

    en.wikipedia.org/wiki/Vertical_transmission

    Complex interdependence occurs between host and symbiont. [5] The genetic pool of the symbiont is generally smaller and more subject to genetic drift. [6] In true vertical transmission, the evolutionary outcomes of the host and symbiont are linked. [7] If there is mixed transmission, new genetic material may be introduced. [8]

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