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List of side effects of estradiol which may occur as a result of its use or have been associated with estrogen and/or progestogen therapy includes: [1] [2]. Gynecological: changes in vaginal bleeding, dysmenorrhea, increase in size of uterine leiomyomata, vaginitis including vaginal candidiasis, changes in cervical secretion and cervical ectropion, ovarian cancer, endometrial hyperplasia ...
Estrone has been used by intramuscular injection at a dosage of 0.1 to 2 mg per week, or 0.1 to 0.5 mg given 2 or 3 times per week, for the treatment of menopausal symptoms such as hot flashes and vaginal atrophy, [20] [21] and at a dosage of 0.1 to 1.0 mg weekly in single or divided doses for the treatment of female hypogonadism, surgical ...
Estrone, also known as estra-1,3,5(10)-trien-3-ol-17-one, is a naturally occurring estrane steroid with double bonds at the C1, C3, and C5 positions, a hydroxyl group at the C3 position, and a ketone group at the C17 position. The name estrone was derived from the chemical terms estrin (estra-1,3,5(10)-triene) and ketone.
Side effects of estradiol in women include breast tenderness, breast enlargement, headache, fluid retention, and nausea among others. [ 11 ] [ 20 ] Men and children who are exposed to estradiol may develop symptoms of feminization , such as breast development and a feminine pattern of fat distribution , and men may also experience low ...
Side effects of estradiol acetate include breast tenderness, breast enlargement, nausea, headache, and fluid retention. [7] [5] [6] Estradiol acetate is an estrogen and hence is an agonist of the estrogen receptor, the biological target of estrogens like estradiol. [8] [9] It is an estrogen ester and a prodrug of estradiol in the body.
E1S, also known as estrone 3-sulfate or as estra-1,3,5(10)-trien-17-one 3-sulfate, is a naturally occurring estrane steroid and a derivative of estrone. [15] It is an estrogen conjugate or ester, and is specifically the C3 sulfate ester of estrone. [15] Salts of E1S include sodium estrone sulfate and estropipate (piperazine estrone sulfate ...
Estradiol valerate by intramuscular injection is usually used at a dosage of 10 to 20 mg every 4 weeks in the treatment of menopausal symptoms and hypoestrogenism due to hypogonadism, castration, or primary ovarian failure in women. [13] In the past, it was used at even higher doses of 10 to 40 every 1 to 4 weeks for estrogen replacement. [36]
[84] [85] [86] The preceding side effects of synthetic estrogens do not appear to occur in pregnant women, who already have very high estrogen levels. [84] This suggests that these effects are due to estrogenic activity. [84] Synthetic estrogens have markedly stronger effects on the liver and hepatic protein synthesis than natural estrogens.