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Long-term potentiation (LTP) is a persistent increase in synaptic strength following high-frequency stimulation of a chemical synapse. Studies of LTP are often carried out in slices of the hippocampus, an important organ for learning and memory. In such studies, electrical recordings are made from cells and plotted in a graph such as this one.
It has been proposed that long-term potentiation is composed of at least two different phases: [4] protein synthesis-independent E-LTP (early LTP) and protein synthesis-dependent L-LTP (late LTP). A single train of high-frequency stimuli is needed to trigger E-LTP that begins right after the stimulation, lasting a few hours or less, and ...
The 3 core sciences namely Biology, Chemistry, and Physics will be updated for first teaching in August 2023, with first examinations in May 2025. The syllabus change was originally scheduled for 2021, though the COVID-19 pandemic caused the IB to delay the syllabus change to 2023. Details of the specific changes can be found on the IBO website.
The induction of NMDA receptor-dependent long-term potentiation (LTP) in chemical synapses in the brain occurs via a fairly straightforward mechanism. [1] [2] A substantial and rapid rise in calcium ion concentration inside the postsynaptic cell (or more specifically, within the dendritic spine) is most possibly all that is required to induce LTP.
Plant lipid transfer proteins, also known as plant LTPs or PLTPs, are a group of highly-conserved proteins of about 7-9kDa found in higher plant tissues. [ 1 ] [ 2 ] As its name implies, lipid transfer proteins facilitate the shuttling of phospholipids and other fatty acid groups between cell membranes . [ 3 ]
Long-term potentiation (LTP) of synaptic strength at Schaffer collateral synapses has largely been attributed to changes in the number and biophysical properties of AMPA receptors (AMPARs). [8] Neuropsin has a regulatory effect on Schaffer collateral LTP in the rat hippocampus. [7] The functional hippocampus needs to store long-term memories.
Fructose is a natural sugar found in fruits, vegetables, and honey. Fructose can be bad for your health when consumed as part of high-fructose corn syrup in processed foods. Past studies have ...
Synaptotagmin variants have been implicated in the enhancement of neural connections, leading to long-term potentiation (LTP) in synapses. The localization of synaptotagmin to the endoplasmic reticulum in the cytoplasm drives the growth of these synapses. [ 18 ]