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Hydromorphone is a semi-synthetic μ-opioid agonist. As a hydrogenated ketone of morphine, it shares the pharmacologic properties typical of opioid analgesics. Hydromorphone and related opioids produce their major effects on the central nervous system and gastrointestinal tract.
Side effects. Common side effects of hydrocodone are nausea, vomiting, constipation, drowsiness, dizziness, lightheadedness, anxiety, abnormally happy or sad mood, dry throat, difficulty urinating, rash, itching, and contraction of the pupils. Serious side effects include slowed or irregular breathing and chest tightness.
Oxycodone/naloxone. Oxycodone/naloxone, sold under the brand name Targin among others, is a combination pain medication. It is available as modified-release tablets and is taken by mouth. [5] The oxycodone component is an opioid and is responsible for the pain-relieving effects. Naloxone opposes the effects of opioids but is poorly absorbed ...
Oxycodone is available as a controlled-release tablet. [29] A 2006 review found that controlled-release oxycodone is comparable to immediate-release oxycodone, morphine, and hydromorphone in management of moderate to severe cancer pain, with fewer side effects than morphine.
Its effects last for about four to six hours. Codeine exhibits abuse potential similar to other opioid medications, including a risk of habituation and overdose. [4] Common side effects include vomiting, constipation, itchiness, lightheadedness, and drowsiness. [4] Serious side effects may include breathing difficulties and addiction. [4]
Oxymorphone (sold under the brand names Numorphan and Opana among others) is a highly potent opioid analgesic indicated for treatment of severe pain. Pain relief after injection begins after about 5–10 minutes, after oral administration it begins after about 30 minutes, and lasts about 3–4 hours for immediate-release tablets and 12 hours for extended-release tablets. [6]
Common side effects of morphine include drowsiness, nausea, vomiting, dizziness, sweating, and constipation. [12] Caution is advised for use of morphine during pregnancy or breast feeding, as it may affect the health of the baby. [12] [2] Morphine was first isolated between 1803 and 1805 by German pharmacist Friedrich Sertürner. [16]
Loperamide, sold under the brand name Imodium, among others, [1] is a medication of the opioid receptor agonist class used to decrease the frequency of diarrhea. [5] [4] It is often used for this purpose in irritable bowel syndrome, inflammatory bowel disease, short bowel syndrome [4] Crohn's disease and ulcerative colitis. [5]
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