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C. botulinum is a soil bacterium. The spores can survive in most environments and are very hard to kill. They can survive the temperature of boiling water at sea level, thus many foods are canned with a pressurized boil that achieves even higher temperatures, sufficient to kill the spores.
Clostridium botulinum is a ubiquitous soil-dwelling bacterium. Many infant botulism patients have been demonstrated to live near a construction site or an area of soil disturbance. [7] Infant botulism has been reported in 49 of 50 US states (all save for Rhode Island), [4] and cases have been recognized in 26 countries on five continents. [8]
Clostridium is a genus of anaerobic, Gram-positive bacteria.Species of Clostridium inhabit soils and the intestinal tracts of animals, including humans. [1] This genus includes several significant human pathogens, including the causative agents of botulism and tetanus.
While tetanus toxin is produced from Clostridium tetani, a spore forming bacteria found in soil, Tetanus is a paralytic disease that is global and commonly affects newborns as well as non-immunized individuals. Tetanus enters the body of organisms through wounds or skin breaks and can be found in manure, soil, and dust.
Botulinum toxin, or botulinum neurotoxin (commonly called botox), is a neurotoxic protein produced by the bacterium Clostridium botulinum and related species. [24] It prevents the release of the neurotransmitter acetylcholine from axon endings at the neuromuscular junction, thus causing flaccid paralysis. [25]
Endospores are commonly found in soil and water, where they may survive for long periods of time. A variety of different microorganisms form "spores" or "cysts", but the endospores of low G+C gram-positive bacteria are by far the most resistant to harsh conditions. [3]
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BAT is the only FDA-approved product available for treating botulism in adults, and for botulism in infants caused by botulinum toxins other than types A and B. BAT has been used to treat a case of type F infant botulism and, on a case-by-case basis, may be used for future cases of non-type A and non-type B infant botulism. [4]