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Mapping of several bone diseases onto levels of vitamin D (calcidiol) in the blood [6] Normal bone vs. osteoporosis. Vitamin D deficiency is typically diagnosed by measuring the concentration of the 25-hydroxyvitamin D in the blood, which is the most accurate measure of stores of vitamin D in the body.
Clinical trials of vitamin D supplementation for depressive symptoms have generally been of low quality and show no overall effect, although subgroup analysis showed supplementation for participants with clinically significant depressive symptoms or depressive disorder had a moderate effect. [149]
There is limited evidence that vitamin D supplementation is of value in alleviating the symptoms of depression in individuals who are vitamin D-deficient. [102] Lithium appears effective at lowering the risk of suicide in those with bipolar disorder and unipolar depression to nearly the same levels as the general population. [218]
Vitamin B 6: pyridoxal phosphate (PLP), the active form of B 6, is a cofactor in the dopamine serotonin pathway, a deficiency in vitamin B 6 may cause depressive symptoms. [ 98 ] Folate (vitamin B 9 ) – Vitamin B 12 cobalamin: Low blood plasma and particularly red cell folate and diminished levels of vitamin B 12 have been found in patients ...
Vitamin D deficiency: Usually asymptomatic, causes reduce bone density (osteomalacia), rickets, myopathy, and is associated with the development of schizophrenia. It is typically diagnosed by measuring the concentration of the 25-hydroxyvitamin D (25(OH)D) in plasma, which is the most accurate measure of stores of vitamin D in the body ...
Optogenetic excitation of D1-MSNs alleviates depressive symptoms and is rewarding, while the same with D2-MSNs enhances depressive symptoms. Excitation of glutaminergic inputs from the ventral hippocampus reduces social interactions, and enhancing these projections produces susceptibility to stress-induced depression. [136]
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Vitamin D (the inactive version) is mainly from two forms: vitamin D 3 and vitamin D 2. Vitamin D 3, or cholecalciferol, is formed in the skin after exposure to sunlight or ultra violet radiation or from D 3 supplements or fortified food sources. Vitamin D 2, or ergocalciferol, is obtained from D 2 supplements or fortified food sources. [3]
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