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"Indiana University Department of Medicine Clinical Pharmacology Drug Interactions Flockhart Table ™". "INHIBITORS, INDUCERS AND SUBSTRATES OF CYTOCHROME P450 ISOZYMES". "The Life Raft Group: Long List of Inhibitors and Inducers of CYP3A4 and CYP2D6". "DRUGBANK Online: Cytochrome P-450 Enzyme Inhibitors".
Following is a table of selected substrates, inducers and inhibitors of CYP1A2. Inhibitors of CYP1A2 can be classified by their potency , such as: Strong inhibitor being one that causes at least a 5-fold increase in the plasma AUC values of sensitive substrates metabolized through CYP1A2, or more than 80% decrease in clearance thereof.
Flockhart DA (2008-09-04). "Human Cytochrome P450 (CYP) Allele Nomenclature Committee". Karolinska Institutet; Sigaroudi A, Vollbrecht H (2019). "pharmacokinetic interaction table". Sigaroudi & Vollbrecht. Sim SC (2007). "Cytochrome P450 drug interaction table". Indiana University-Purdue University Indianapolis
When two drugs affect each other, it is a drug–drug interaction (DDI). The risk of a DDI increases with the number of drugs used. [1] A large share of elderly people regularly use five or more medications or supplements, with a significant risk of side-effects from drug–drug interactions. [2] Drug interactions can be of three kinds ...
Any antiretroviral drug: Black tar heroin: Whoonga, Nyaope [8] Widespread use in South Africa. Whoonga is classically reputed to be a combination of heroin with antiretroviral drugs such as ritonavir and/or efavirenz, often combined with additional drugs such as cannabis or hashish, methamphetamine and/or methaqualone: Any deliriant or diphen ...
Index inducer or just inducer predictably induce metabolism via a given pathway and are commonly used in prospective clinical drug-drug interaction studies. [2]Strong, moderate, and weak inducers are drugs that decreases the AUC of sensitive index substrates of a given metabolic pathway by ≥80%, ≥50% to <80%, and ≥20% to <50%, respectively.
1555 13088 Ensembl ENSG00000197408 ENSMUSG00000030483 UniProt P20813 P12791 RefSeq (mRNA) NM_000767 NM_009999 RefSeq (protein) NP_000758 n/a Location (UCSC) Chr 19: 40.99 – 41.02 Mb Chr 7: 25.6 – 25.63 Mb PubMed search Wikidata View/Edit Human View/Edit Mouse Cytochrome P450 2B6 is an enzyme that in humans is encoded by the CYP2B6 gene. CYP2B6 is a member of the cytochrome P450 group of ...
13106 Ensembl ENSG00000130649 ENSMUSG00000025479 UniProt P05181 Q05421 RefSeq (mRNA) NM_000773 NM_021282 RefSeq (protein) NP_000764 NP_067257 Location (UCSC) Chr 10: 133.52 – 133.56 Mb Chr 7: 140.34 – 140.35 Mb PubMed search Wikidata View/Edit Human View/Edit Mouse Cytochrome P450 2E1 (abbreviated CYP2E1, EC 1.14.13.n7) is a member of the cytochrome P450 mixed-function oxidase system ...