Ad
related to: spironolactone vs eplerenone side effects- 109 S High St #100, Columbus, OH · Directions · (614) 224-4261
A prescription drug card that actually does work - BBB.org
- How GoodRx® Works
Get Rx Coupons, Save Up to 80%
No Commitment & No Fees
- GoodRx® Press
"Shop wisely with GoodRx"
Featured on CNN & Forbes.
- GoodRx® Blog
Get the Latest Healthcare News
Find What Matters Most to You
- Healthcare Professionals
GoodRx® Can Help You Get Major
Savings For Your Patients
- How GoodRx® Works
Search results
Results from the WOW.Com Content Network
Eplerenone may have a lower incidence than spironolactone of sexual side effects such as feminization, gynecomastia, impotence, low sex drive and reduction of size of male genitalia. [18] This is because other antimineralocorticoids have structural elements of the progesterone molecule, causing progestogenic and antiandrogenic outcomes. [ 4 ]
High doses of spironolactone, which are needed for considerable antiandrogenic effects, are not recommended for men due to the high risk of feminization and other side effects. Spironolactone can be used to treat symptoms of hyperandrogenism , such as due to polycystic ovary syndrome .
Eplerenone is a newer drug that was developed as a spironolactone analog with reduced adverse effects. In addition to the y-lactone ring and the substituent on C-7, eplerenone has a 9α,11α-epoxy group. This group is believed to be the reason why eplerenone has a 20-40-fold lower affinity for the mineralocorticoid receptor than spironolactone. [7]
[28] [16] In addition, the AR antagonism of spironolactone is involved in its feminizing side effects, such as gynecomastia in men. [28] Spironolactone has been found to produce gynecomastia without changes in testosterone or estradiol levels, implicating AR antagonism in this side effect. [30] Gynecomastia is a major known side effect of AR ...
Triamterene – increased renal side-effects; Aldosterone antagonists, also known as mineralocorticoid receptor antagonists: [7] Spironolactone – most widespread use, inexpensive; Eplerenone – more selective so reduced side-effects but more expensive and less potent
eplerenone; spironolactone; Aldosterone receptor antagonists are not recommended as first-line agents for blood pressure, [47] but spironolactone and eplerenone are both used in the treatment of heart failure and resistant hypertension.
For people with hyperplasia of both glands, successful treatment is often achieved with spironolactone or eplerenone, drugs that block the aldosterone receptor. With its antiandrogen effect, spironolactone drug therapy may have a range of side effects in males and females, including gynecomastia and irregular menses. These symptoms occur less ...
For potassium-sparing diuretics, its common side effects include hyponatremia, hyperkalemia, metabolic acidosis and sexual dysfunction specifically for spironolactone. [ 4 ] [ 5 ] The use of diuretics should be avoided in patients with severe dehydration, anuria (absence of urine production). [ 4 ]
Ad
related to: spironolactone vs eplerenone side effects- 109 S High St #100, Columbus, OH · Directions · (614) 224-4261
A prescription drug card that actually does work - BBB.org