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It is in the penicillin and beta lactam class of medications and works via benzylpenicillin. [3] [5] The benzathine component slowly releases the penicillin making the combination long acting. [7] Benzathine benzylpenicillin was patented in 1950. [2] [8] It is on the World Health Organization's List of Essential Medicines. [9]
Two long-acting forms benzathine benzylpenicillin and procaine benzylpenicillin are available for use by injection into a muscle only. [6] Side effects include diarrhea, seizures, and allergic reactions including anaphylaxis. [6] When used to treat syphilis or Lyme disease a reaction known as Jarisch–Herxheimer may occur. [6]
Long-acting, broad-spectrum antibiotics offer the following advantages by comparison to short-acting antimicrobials in perioperative prophylaxis: [citation needed] A single dose covers the whole perioperative risk period - even if the operation is delayed or long-lasting - and with regard to respiratory and urinary tract infections
Penicillin G is the preferred antibiotic for syphilis. Also known as penicillin G potassium or benzylpenicillin, this long-acting antibiotic is given by intramuscular (IM) injection into a large ...
History of penicillin. The history of penicillin follows observations and discoveries of evidence of antibiotic activity of the mould Penicillium that led to the development of penicillins that became the first widely used antibiotics. Following the production of a relatively pure compound in 1942, penicillin was the first naturally-derived ...
The first long-acting (depot) injections were antipsychotics fluphenazine and haloperidol. [2] The concept of a depot injection arose before 1950, and originally was used to describe antibiotic injections that lasted longer to allow for less frequent administration. [4]
Procaine benzylpenicillin also known as penicillin G procaine, is an antibiotic useful for the treatment of a number of bacterial infections. [2] Specifically it is used for syphilis, anthrax, mouth infections, pneumonia, diphtheria, cellulitis, and animal bites. [2] It is given by injection into a muscle.
Kidneys. Penicillins (P, PCN or PEN) are a group of β-lactam antibiotics originally obtained from Penicillium moulds, principally P. chrysogenum and P. rubens. Most penicillins in clinical use are synthesised by P. chrysogenum using deep tank fermentation [2] and then purified. [3][4] A number of natural penicillins have been discovered, but ...
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