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Hydroxychloroquine is a quinoline drug used to treat or prevent malaria. It's also used to treat symptoms of rheumatoid arthritis, discoid and systemic lupus erythematosus.
Serious side effects of hydroxychloroquine. Along with its needed effects, hydroxychloroquine may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention. Check with your doctor immediately if any of the following side effects occur while taking hydroxychloroquine:
An overdose of hydroxychloroquine can be fatal, and must be treated quickly. Overdose symptoms may include drowsiness, vision changes, seizure, slow heart rate, weak pulse, pounding heartbeats, sudden dizziness, fainting, shortness of breath, or slow breathing (breathing may stop). Keep this medicine out of the reach of children.
Multiple studies have provided data demonstrating that hydroxychloroquine is ineffective in the treatment of SARS-CoV-2, the virus that causes COVID-19 disease. The RECOVERY Trial from the University of Oxford is a large, randomized, controlled, open-label study evaluating a number of potential treatments for patients hospitalized with COVID-19.
Maintenance dose: 200 to 400 mg salt (155 to 310 mg base)/day orally divided in 1 or 2 doses. Maximum dose: 600 mg salt (465 mg base)/day or 6.5 mg/kg salt (5 mg/kg base)/day, whichever is lower. Comments: The action of this drug is cumulative and may require weeks to months to achieve the maximum therapeutic effect.
Initial dosage: 400–600 mg of hydroxychloroquine sulfate daily given as a single dose or in 2 divided doses. Chronic maintenance dosage: 200 mg of hydroxychloroquine sulfate once daily or 400 mg daily given as a single dose or in 2 divided doses. Therapeutic effects are cumulative; maximum effects may require weeks to months of treatment.
Hydroxychloroquine Interactions. There are 470 drugs known to interact with hydroxychloroquine, along with 13 disease interactions, and 1 alcohol/food interaction. Of the total drug interactions, 192 are major, 275 are moderate, and 3 are minor.
Hydroxychloroquine is a weak base and may exert its effect by concentrating in the acid vesicles of the parasite and inhibiting polymerization of heme. It can also inhibit certain enzymes by its interaction with DNA. Antimicrobial Activity. Hydroxychloroquine is active against the erythrocytic forms of chloroquine sensitive strains of
Hydroxychloroquine has an average rating of 6.5 out of 10 from a total of 354 ratings on Drugs.com. 53% of reviewers reported a positive effect, while 27% reported a negative effect. Quinine has an average rating of 8.9 out of 10 from a total of 20 ratings on Drugs.com. 94% of reviewers reported a positive effect, while 6% reported a negative ...
Hydroxychloroquine User Reviews & Ratings. Brand names: Plaquenil, Sovuna. Hydroxychloroquine has an average rating of 6.5 out of 10 from a total of 344 reviews on Drugs.com. 53% of reviewers reported a positive experience, while 27% reported a negative experience. Condition.